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Gary D. Lopaschuk
Researcher at University of Alberta
Publications - 406
Citations - 38016
Gary D. Lopaschuk is an academic researcher from University of Alberta. The author has contributed to research in topics: Beta oxidation & Heart failure. The author has an hindex of 96, co-authored 387 publications receiving 33826 citations. Previous affiliations of Gary D. Lopaschuk include Cornell University & University of British Columbia.
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Journal ArticleDOI
Myocardial Substrate Metabolism in the Normal and Failing Heart
TL;DR: This review discusses the metabolic changes that occur in chronic heart failure, with emphasis on the mechanisms that regulate the changes in the expression of metabolic genes and the function of metabolic pathways and the consequences of these metabolic changes on cardiac function.
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Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
Timothy R. Koves,John R. Ussher,Robert C. Noland,Dorothy H. Slentz,Merrie Mosedale,Olga Ilkayeva,James R. Bain,Robert Stevens,Jason R.B. Dyck,Christopher B. Newgard,Gary D. Lopaschuk,Deborah M. Muoio +11 more
TL;DR: Target metabolomics finds that obesity-related insulin resistance in skeletal muscle is characterized by excessive beta-oxidation, impaired switching to carbohydrate substrate during the fasted-to-fed transition, and coincident depletion of organic acid intermediates of the tricarboxylic acid cycle.
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Myocardial Fatty Acid Metabolism in Health and Disease
TL;DR: The regulation of myocardial fatty acid beta-oxidation is reviewed and how alterations in fatty acid Beta-Oxidation can contribute to heart disease is discussed.
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A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
Sébastien Bonnet,Stephen L. Archer,Joan Allalunis-Turner,Alois Haromy,Christian Beaulieu,Richard B. Thompson,Christopher T. Lee,Gary D. Lopaschuk,Lakshmi Puttagunta,Sandra Bonnet,Gwyneth Harry,Kyoko Hashimoto,Christopher J. Porter,Miguel A. Andrade,Bernard Thébaud,Evangelos D. Michelakis +15 more
TL;DR: The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted and the orally available DCA is a promising selective anticancer agent.
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The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
Brian N. Finck,John J. Lehman,Teresa C. Leone,Michael J. Welch,Michael J. Bennett,Attila Kovacs,Xianlin Han,Richard W. Gross,Ray Kozak,Gary D. Lopaschuk,Daniel P. Kelly +10 more
TL;DR: PPARalpha is a critical regulator of myocardial fatty acid uptake and utilization, activation of cardiac PPARalpha regulatory pathways results in a reciprocal repression of glucose uptake and usage pathways, and derangements in myocardian energy metabolism typical of the diabetic heart can become maladaptive, leading to cardiomyopathy.