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Geoffrey Fudenberg
Researcher at Gladstone Institutes
Publications - 61
Citations - 17372
Geoffrey Fudenberg is an academic researcher from Gladstone Institutes. The author has contributed to research in topics: Chromatin & Chromosome conformation capture. The author has an hindex of 29, co-authored 56 publications receiving 14487 citations. Previous affiliations of Geoffrey Fudenberg include Columbia University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Ultrahigh electron mobility in suspended graphene
Kirill I. Bolotin,K. J. Sikes,Zhigang Jiang,Martin Klima,Geoffrey Fudenberg,James Hone,Philip Kim,Horst Stormer,Horst Stormer +8 more
TL;DR: In this paper, a single layer graphene was suspended ∼150nm above a Si/SiO2 gate electrode and electrical contacts to the graphene was achieved by a combination of electron beam lithography and etching.
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Formation of Chromosomal Domains by Loop Extrusion
Geoffrey Fudenberg,Maxim Imakaev,Carolyn Lu,Anton Goloborodko,Nezar Abdennur,Leonid A. Mirny,Leonid A. Mirny +6 more
TL;DR: This model produces TADs and finer-scale features of Hi-C data because each TAD emerges from multiple loops dynamically formed through extrusion, contrary to typical illustrations of single static loops.
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Iterative correction of Hi-C data reveals hallmarks of chromosome organization
Maxim Imakaev,Geoffrey Fudenberg,Rachel Patton McCord,Natalia Naumova,Anton Goloborodko,Bryan R. Lajoie,Job Dekker,Leonid A. Mirny,Leonid A. Mirny +8 more
TL;DR: In this article, the authors present a pipeline that integrates a strategy for mapping of sequencing reads and a data-driven method for iterative correction of biases, yielding genome-wide maps of relative contact probabilities.
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Two independent modes of chromatin organization revealed by cohesin removal
Wibke Schwarzer,Nezar Abdennur,Anton Goloborodko,Aleksandra Pekowska,Geoffrey Fudenberg,Yann Loe-Mie,Nuno A. Fonseca,Wolfgang Huber,Christian H. Haering,Leonid A. Mirny,François Spitz +10 more
TL;DR: It is shown that deletion of the cohesin-loading factor Nipbl in mouse liver leads to a marked reorganization of chromosomal folding, and the disappearance of TADs unmasks a finer compartment structure that accurately reflects the underlying epigenetic landscape.
Journal ArticleDOI
Organization of the Mitotic Chromosome
Natalia Naumova,Maxim Imakaev,Geoffrey Fudenberg,Geoffrey Fudenberg,Ye Zhan,Bryan R. Lajoie,Leonid A. Mirny,Job Dekker +7 more
TL;DR: Using polymer simulations, it is found that metaphase Hi-C data are inconsistent with classic hierarchical models and are instead best described by a linearly organized longitudinally compressed array of consecutive chromatin loops.