G
Gerd Heusch
Researcher at University of Duisburg-Essen
Publications - 607
Citations - 41690
Gerd Heusch is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Ischemic preconditioning & Ischemia. The author has an hindex of 105, co-authored 582 publications receiving 37291 citations. Previous affiliations of Gerd Heusch include University of Hamburg & Charité.
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Journal ArticleDOI
A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy
Denise Hilfiker-Kleiner,Karol Kamiński,Edith Podewski,Tomasz A. Bonda,Arnd Schaefer,Karen Sliwa,Olaf Forster,Anja Quint,Ulf Landmesser,Carola Doerries,Maren Luchtefeld,Valeria Poli,Michael D. Schneider,Jean-Luc Balligand,Fanny Desjardins,Aftab A. Ansari,Ingrid Struman,Ngoc Quynh Nhu Nguyen,Nils H. Zschemisch,Gunnar Klein,Gerd Heusch,Rainer Schulz,Andres Hilfiker,Helmut Drexler +23 more
TL;DR: It is shown that female mice with a cardiomyocyte-specific deletion of stat3 develop PPCM, implying that inhibition of prolactin release may represent a novel therapeutic strategy for P PCM.
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Evolving therapies for myocardial ischemia/reperfusion injury.
TL;DR: The past, present, and future therapies to reduce ischemia/reperfusion injury are examined; few interventions have successfully passed the proof-of-concept stage.
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Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.
Tilley Pain,X.-M. Yang,Stuart D. Critz,Yankun Yue,Atsushi Nakano,Guang S. Liu,Gerd Heusch,Michael V. Cohen,James M. Downey +8 more
TL;DR: Mito KATP channels are not the end effectors of protection, but rather their opening before ischemia generates free radicals that trigger entrance into a preconditioned state and activation of kinases, indicating that diazoxide triggers protection through free radicals.
Journal ArticleDOI
Molecular Basis of Cardioprotection: Signal Transduction in Ischemic Pre-, Post-, and Remote Conditioning
TL;DR: The present review characterizes the signalTransduction underlying the conditioning phenomena, including their physical and chemical triggers, intracellular signal transduction, and effector mechanisms, notably in the mitochondria, as a highly concerted spatiotemporal program.
Journal ArticleDOI
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals.
Petra Kleinbongard,Andre Dejam,Thomas Lauer,Tienush Rassaf,Tienush Rassaf,A.W. Schindler,Olaf Picker,Thomas Scheeren,Axel Gödecke,Jürgen Schrader,Rainer Schulz,Gerd Heusch,Günter A. Schaub,Nathan S. Bryan,Martin Feelisch,Malte Kelm +15 more
TL;DR: Evidence is provided for a uniform constitutive vascular NOS-activity across mammalian species by determining plasma nitrite concentration to be in a nanomolar range in a variety of species.