G
Gertraud Orend
Researcher at University of Strasbourg
Publications - 72
Citations - 5449
Gertraud Orend is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Tenascin C & Extracellular matrix. The author has an hindex of 30, co-authored 64 publications receiving 4660 citations. Previous affiliations of Gertraud Orend include Novartis & Discovery Institute.
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Journal ArticleDOI
Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
Kim S. Midwood,Sandra Sacre,Anna M. Piccinini,Julia J. Inglis,Annette Trebaul,Annette Trebaul,Emma Chan,Emma Chan,Stefan K. Drexler,Stefan K. Drexler,Nidhi Sofat,Masahide Kashiwagi,Gertraud Orend,Fionula M. Brennan,Brian M. J. Foxwell +14 more
TL;DR: Tenascin-C is identified as a novel endogenous activator of TLR4-mediated immunity that mediates persistent synovial inflammation and tissue destruction in arthritic joint disease.
Journal ArticleDOI
Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage
TL;DR: The cyclin E-CDK2 complex, which is required for the G1-S transition of the cell cycle, was activated in late G1 phase in attached human fibro Blasts, but not in fibroblasts maintained in suspension, and in transformed fibroblast the complex was active regardless of attachment.
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The role of tenascin-C in tissue injury and tumorigenesis.
TL;DR: Hopes are generated that increased knowledge about tenascin-C will further improve management of diseases with high tenascInC expression such as chronic inflammation, heart failure, artheriosclerosis and cancer.
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Tenascin-C induced signaling in cancer.
TL;DR: How tenascin-C affects malignant transformation, uncontrolled proliferation, angiogenesis, metastasis and escape from tumor immunosurveillance and how this knowledge could be applied to cancer therapy is discussed.
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CD24 Expression Causes the Acquisition of Multiple Cellular Properties Associated with Tumor Growth and Metastasis
Petra Baumann,Natascha Cremers,Frans Kroese,Gertraud Orend,Ruth Chiquet-Ehrismann,Toshi Uede,Hideo Yagita,Jonathan P. Sleeman +7 more
TL;DR: It is shown that ectopic CD24 expression can be sufficient to promote tumor metastasis in experimental animals and implicate CD24 in the regulation of multiple cell properties of direct relevance to tumor growth and metastasis.