The role of tenascin-C in tissue injury and tumorigenesis.
TLDR
Hopes are generated that increased knowledge about tenascin-C will further improve management of diseases with high tenascInC expression such as chronic inflammation, heart failure, artheriosclerosis and cancer.Abstract:
The extracellular matrix molecule tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer. Tenascin-C interacts with several other extracellular matrix molecules and cell-surface receptors, thus affecting tissue architecture, tissue resilience and cell responses. Tenascin-C modulates cell migration, proliferation and cellular signaling through induction of pro-inflammatory cytokines and oncogenic signaling molecules amongst other mechanisms. Given the causal role of inflammation in cancer progression, common mechanisms might be controlled by tenascin-C during both events. Drugs targeting the expression or function of tenascin-C or the tenascin-C protein itself are currently being developed and some drugs have already reached advanced clinical trials. This generates hope that increased knowledge about tenascin-C will further improve management of diseases with high tenascin-C expression such as chronic inflammation, heart failure, artheriosclerosis and cancer.read more
Citations
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Matricellular Proteins in Cardiac Adaptation and Disease
TL;DR: Understanding the role of matricellular proteins in myocardial pathophysiology and identification of the functional domains responsible for their actions may lead to design of peptides with therapeutic potential for patients with heart disease.
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The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer
TL;DR: The functional contributions of myofibroblasts, CAFs, and fibrosis to the development of HCC and CCA in the hepatic PME and TME are discussed, focusing on my ofibroblast- and extracellular matrix-associated growth factors, fibrosis-associated immunosuppressive pathways, as well as mechanosensitive signaling cascades that are activated by increased tissue stiffness.
Journal ArticleDOI
Tenascin-C at a glance.
TL;DR: Tenascin-C is an extracellular matrix molecule that shapes cell behavior in developing and traumatized tissues, and has a great potential in disease diagnosis and tissue repair.
Journal ArticleDOI
Advances in tenascin-C biology
TL;DR: The molecular mechanisms by which tenascin-C mediates these effects and the implications of mis-regulated tenascInC expression in driving disease pathology are highlighted.
Journal ArticleDOI
Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression.
Yekaterina A. Miroshnikova,Janna K. Mouw,J. Matthew Barnes,Michael W. Pickup,Johnathan N. Lakins,Youngmi Kim,Khadjia Lobo,Anders Persson,Gerald F. Reis,Tracy R. McKnight,Eric C. Holland,Joanna J. Phillips,Valerie M. Weaver +12 more
TL;DR: It is found that glioma aggression and patient prognosis correlate with HIF1α levels and the stiffness of a tenascin C (TNC)-enriched ECM, and this work suggests that elevated ECM stiffness can independently foster glioblastomas aggression and contribute to gliOBlastoma recurrence via bypassing the protective activity of IDH1 mutational status.
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