G
Gillian Dekkers
Researcher at University of Amsterdam
Publications - 25
Citations - 3024
Gillian Dekkers is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Antibody & Immunoglobulin G. The author has an hindex of 16, co-authored 24 publications receiving 2171 citations. Previous affiliations of Gillian Dekkers include Medical Research Council.
Papers
More filters
Journal ArticleDOI
IgG subclasses and allotypes: from structure to effector functions.
TL;DR: IgG-polymorphisms and post-translational modification of the antibodies in the form of glycosylation, affect IgG-function will be the focus of the current review.
Journal ArticleDOI
Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities.
Gillian Dekkers,Louise W. Treffers,Rosina Plomp,Arthur E. H. Bentlage,Marcella de Boer,Carolien A. M. Koeleman,Suzanne N. Lissenberg-Thunnissen,Remco Visser,Mieke C. Brouwer,Juk Yee Mok,Hanke L. Matlung,Timo K. van den Berg,Wim J E van Esch,Taco W. Kuijpers,Diana Wouters,Theo Rispens,Manfred Wuhrer,Gestur Vidarsson +17 more
TL;DR: Fucosylation and galactOSylation are primary mediators of functional changes in IgG for FcγR- and complement-mediated effector functions, respectively, with galactose having an auxiliary role for F cγRIII-mediated functions.
Journal ArticleDOI
Affinity of human IgG subclasses to mouse Fc gamma receptors
Gillian Dekkers,Arthur E. H. Bentlage,Tamara C. Stegmann,Heather L. Howie,Suzanne N. Lissenberg-Thunnissen,James C. Zimring,Theo Rispens,Gestur Vidarsson +7 more
TL;DR: Binding affinities of all mouse and human IgG subclasses to mouse FcγR are reported, which suggests human IgGs sub classes to have similar relative FcαγR-mediated biological activities in mice.
Journal ArticleDOI
Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans
Gillian Dekkers,Rosina Plomp,Carolien A. M. Koeleman,Remco Visser,Hans Henning von Horsten,Volker Sandig,Theo Rispens,Manfred Wuhrer,Gestur Vidarsson +8 more
TL;DR: General methods to produce recombinant proteins of any desired glycoform in eukaryotic cells are described and the biological effect of these glycosylation traits for IgG and other glycoproteins are systematically explored.
Journal ArticleDOI
Identification of sequence variants influencing immunoglobulin levels.
Stefan Jonsson,Gardar Sveinbjornsson,Aitzkoa Lopez de Lapuente Portilla,Bhairavi Swaminathan,Rosina Plomp,Gillian Dekkers,Ram Ajore,Mina Ali,Arthur E. H. Bentlage,Evelina Elmér,Gudmundur I. Eyjolfsson,Sigurjon A. Gudjonsson,Urban Gullberg,Arnaldur Gylfason,Bjarni V. Halldorsson,Markus Hansson,Hilma Holm,Åsa Johansson,Ellinor Johnsson,Aslaug Jonasdottir,Bjorn R. Ludviksson,Asmundur Oddsson,Isleifur Olafsson,Sigurgeir Olafsson,Olof Sigurdardottir,Asgeir Sigurdsson,Lilja Stefansdottir,Gisli Masson,Patrick Sulem,Manfred Wuhrer,Anna-Karin Wihlborg,Gudmar Thorleifsson,Daniel F. Gudbjartsson,Unnur Thorsteinsdottir,Gestur Vidarsson,Ingileif Jonsdottir,Björn Nilsson,Björn Nilsson,Kari Stefansson +38 more
TL;DR: A genome-wide association study of 19,219 individuals found 38 new variants and replicated 5 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, accounted for by 32 loci.