G
Gestur Vidarsson
Researcher at University of Amsterdam
Publications - 159
Citations - 9268
Gestur Vidarsson is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Antibody & Immunoglobulin G. The author has an hindex of 44, co-authored 127 publications receiving 6924 citations. Previous affiliations of Gestur Vidarsson include Gulf Coast Regional Blood Center & Leiden University Medical Center.
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Journal ArticleDOI
IgG subclasses and allotypes: from structure to effector functions.
TL;DR: IgG-polymorphisms and post-translational modification of the antibodies in the form of glycosylation, affect IgG-function will be the focus of the current review.
Journal ArticleDOI
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability.
Philip J. M. Brouwer,Tom G. Caniels,Karlijn van der Straten,Jonne L. Snitselaar,Yoann Aldon,Sandhya Bangaru,Jonathan L. Torres,Nisreen M.A. Okba,Mathieu Claireaux,Gius Kerster,Arthur E. H. Bentlage,Marlies M. van Haaren,Denise Guerra,Judith A. Burger,Edith E. Schermer,Kirsten D. Verheul,Niels van der Velde,Alex van der Kooi,Jelle van Schooten,Mariëlle J. van Breemen,Tom P. L. Bijl,Kwinten Sliepen,Aafke Aartse,Aafke Aartse,Ronald Derking,Ilja Bontjer,Neeltje A. Kootstra,W. Joost Wiersinga,Gestur Vidarsson,Bart L. Haagmans,Andrew B. Ward,Godelieve J. de Bree,Rogier W. Sanders,Rogier W. Sanders,Marit J. van Gils +34 more
TL;DR: It is shown that the patients had strong immune responses against the viral spike protein, a complex that binds to receptors on the host cell, and monoclonal antibodies isolated here are promising candidates for COVID-19 treatment and prevention.
Journal ArticleDOI
IgA and the IgA Fc receptor.
Marjolein van Egmond,Cora A. Damen,Annemiek B. van Spriel,Gestur Vidarsson,Evert van Garderen,Jan G. J. van de Winkel +5 more
TL;DR: New insights in the roles of IgA and FcalphaRI are addressed and a model integrating the various functions of Ig a in immunity is discussed, and a new insights inThe role of the myeloid IgA receptor in immunity and its role in innate and adaptive immunity is addressed.
Journal ArticleDOI
Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities.
Gillian Dekkers,Louise W. Treffers,Rosina Plomp,Arthur E. H. Bentlage,Marcella de Boer,Carolien A. M. Koeleman,Suzanne N. Lissenberg-Thunnissen,Remco Visser,Mieke C. Brouwer,Juk Yee Mok,Hanke L. Matlung,Timo K. van den Berg,Wim J E van Esch,Taco W. Kuijpers,Diana Wouters,Theo Rispens,Manfred Wuhrer,Gestur Vidarsson +17 more
TL;DR: Fucosylation and galactOSylation are primary mediators of functional changes in IgG for FcγR- and complement-mediated effector functions, respectively, with galactose having an auxiliary role for F cγRIII-mediated functions.
Journal ArticleDOI
Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential
Nigel M. Stapleton,Jan Terje Andersen,Jan Terje Andersen,Annette M. Stemerding,Stefania P. Bjarnarson,Ruurd C. Verheul,Jorrit Gerritsen,Yixian Zhao,Marion Kleijer,Inger Sandlie,Masja de Haas,Ingileif Jonsdottir,C. Ellen van der Schoot,Gestur Vidarsson +13 more
TL;DR: In this article, a mutation in IgG3 was shown to reduce binding to the neonatal Fc receptor, which can be competitively blocked by IgG1 and IgG2.