G
Graeme P. Young
Researcher at Flinders University
Publications - 471
Citations - 21541
Graeme P. Young is an academic researcher from Flinders University. The author has contributed to research in topics: Colorectal cancer & Contact lens. The author has an hindex of 71, co-authored 452 publications receiving 19226 citations. Previous affiliations of Graeme P. Young include Sewanee: The University of the South & Washington University in St. Louis.
Papers
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Journal Article
Reduced accumulation of specific microRNAs in colorectal neoplasia.
Michael Michael,Susan M. O' Connor,Nicholas G. van Holst Pellekaan,Graeme P. Young,Robert James +4 more
TL;DR: A study was undertaken to investigate possible changes in microRNA levels during tumorigenesis, identifying a total of 28 different miRNA sequences, including 3 novel sequences and a further 7 that had previously been cloned only from mice.
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Colorectal cancer screening: a global overview of existing programmes
Eline H. Schreuders,Arlinda Ruco,Linda Rabeneck,Robert E. Schoen,Joseph J.Y. Sung,Graeme P. Young,Ernst J. Kuipers +6 more
TL;DR: This review highlights issues to consider when implementing a CRC screening programme and gives a worldwide overview of CRC burden and the current status of screening programmes, with focus on international differences.
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Butyrate production from dietary fibre and protection against large bowel cancer in a rat model.
TL;DR: It is indicated that fibre which is associated with high butyrate concentrations in the distal large bowel is protective against large bowel cancer, while soluble fibres that do not raise distal butyrates concentrations, are not protective.
Journal Article
Induction of Caspase-3 Protease Activity and Apoptosis by Butyrate and Trichostatin A (Inhibitors of Histone Deacetylase): Dependence on Protein Synthesis and Synergy with a Mitochondrial/Cytochrome c-dependent Pathway
Vicente Medina,Belinda Edmonds,Graeme P. Young,Robert James,Sarah Appleton,Peter D. Zalewski +5 more
TL;DR: It is proposed that changes at the level of chromatin structure lead to the expression of a protein that facilitates the pathway by which mitochondria activate caspase-3 and trigger apoptotic death of lymphoid and colorectal cancer cells.
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Asia Pacific consensus recommendations for colorectal cancer screening
Joseph J.Y. Sung,James Y.W. Lau,Graeme P. Young,Yasushi Sano,Han-Mo Chiu,Jeong-Sik Byeon,Khay Guan Yeoh,Khean-Lee Goh,Jose D. Sollano,Rungsun Rerknimitr,Takahisa Matsuda,Kai Chun Wu,Simon S.M. Ng,Suet Yi Leung,Govind K. Makharia,Vui Heng Chong,Khek Yu Ho,Durado Brooks,David A. Lieberman,Francis K.L. Chan +19 more
TL;DR: The Asia Pacific Working Group on Colorectal Cancer and international experts launch consensus recommendations aiming to improve the awareness of healthcare providers of the changing epidemiology and screening tests available, as well as reviewing the literature and regional data.