R
Robert James
Researcher at Flinders Medical Centre
Publications - 4
Citations - 2305
Robert James is an academic researcher from Flinders Medical Centre. The author has contributed to research in topics: Adenocarcinoma & Intestinal mucosa. The author has an hindex of 4, co-authored 4 publications receiving 2250 citations.
Papers
More filters
Journal Article
Reduced accumulation of specific microRNAs in colorectal neoplasia.
Michael Michael,Susan M. O' Connor,Nicholas G. van Holst Pellekaan,Graeme P. Young,Robert James +4 more
TL;DR: A study was undertaken to investigate possible changes in microRNA levels during tumorigenesis, identifying a total of 28 different miRNA sequences, including 3 novel sequences and a further 7 that had previously been cloned only from mice.
Journal Article
Induction of Caspase-3 Protease Activity and Apoptosis by Butyrate and Trichostatin A (Inhibitors of Histone Deacetylase): Dependence on Protein Synthesis and Synergy with a Mitochondrial/Cytochrome c-dependent Pathway
Vicente Medina,Belinda Edmonds,Graeme P. Young,Robert James,Sarah Appleton,Peter D. Zalewski +5 more
TL;DR: It is proposed that changes at the level of chromatin structure lead to the expression of a protein that facilitates the pathway by which mitochondria activate caspase-3 and trigger apoptotic death of lymphoid and colorectal cancer cells.
Journal Article
Cdx-2 homeodomain protein expression in human and rat colorectal adenoma and carcinoma.
TL;DR: It is shown that Cdx-2 expression is markedly reduced in the later stages of human colorectal carcinogenesis, namely, high grade dysplasia and invasive carcinoma, which may reflect a concomitant deviation of the neoplastic tissue from the normal intestinal epithelial phenotype.
Journal ArticleDOI
Deconvolution of a complex target using DNA aptamers.
Stephen Fitter,Robert James +1 more
TL;DR: The results show that sequence representation in the selected population changes dramatically with increasing rounds of selection, and it is proposed that aptamer libraries contain sufficient shape diversity to allow deconvolution of a complex mixture of targets.