H
Haitian Lu
Researcher at New York University
Publications - 5
Citations - 1249
Haitian Lu is an academic researcher from New York University. The author has contributed to research in topics: Gene & Phosphorylation. The author has an hindex of 5, co-authored 5 publications receiving 1164 citations.
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Inflammation, a key event in cancer development.
TL;DR: Several recent studies have identified nuclear factor-κB as a key modulator in driving inflammation to cancers, and other proteins with extensive roles in inflammation and cancer, such as signal transducers and activators of transcription, Nrf2, and nuclear factor of activated T cells, are proposed to be promising targets for future studies.
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Carcinogenic effect of nickel compounds.
TL;DR: The present review summarizes the current knowledge on the molecular mechanisms of nickel carcinogenesis, with special emphasis on the role of nickel induced reactive oxygen species (ROS) and signal transduction pathways.
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Molecular mechanisms involved in chemoprevention of black raspberry extracts: from transcription factors to their target genes.
TL;DR: The ability of black raspberries to inhibit tumor development may be mediated by impairing signal transduction pathways leading to activation of AP-1 and NFκB, subsequently resulting in down-regulation of VEGF and COX-2 expression.
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Essential roles of ERKs and p38K in up-regulation of GST A1 expression by Maotai content in human hepatoma cell line Hep3B
TL;DR: Results indicate that certain content in MRWE is able to induce GST A1 ARE transcriptional expression, which may provide protective effects for hepatic cells by antagonizing the oxidative stress derived from ethanol via an ERKs- and p38 K-dependent pathway.
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NFAT3 is required for EGF-induced COX-2 transcription, but neither iNOS transcription nor cell transformation in Cl 41 cells.
TL;DR: It is demonstrated thatNFAT3 is required for EGF-induced COX-2 transcription, but neither iNOS transcription nor cell transformation, indicating that the role of NFAT3 in regulating cell transformation is carcinogen-specific.