H
Hans Häcker
Researcher at St. Jude Children's Research Hospital
Publications - 66
Citations - 11312
Hans Häcker is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 36, co-authored 62 publications receiving 10590 citations. Previous affiliations of Hans Häcker include University of Ulm & University of Utah.
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Journal ArticleDOI
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
Stefan Bauer,Carsten J. Kirschning,Hans Häcker,Vanessa Redecke,Susanne Hausmann,Shizuo Akira,Hermann Wagner,Grayson B. Lipford +7 more
TL;DR: It is shown that human TLR9 expression in human immune cells correlates with responsiveness to bacterial deoxycytidylate-phosphate-deoxyguanylate (CpG)-DNA, and data suggest that hTLR9 conveys CpG-DNA responsiveness to human cells by directly engaging immunostimulating Cpg-DNA.
Journal ArticleDOI
Regulation and Function of IKK and IKK-Related Kinases
Hans Häcker,Michael Karin +1 more
TL;DR: This review describes the functions of and regulatory mechanisms controlling the activity of a family of kinases that are instrumental for activation of the host defense system.
Journal ArticleDOI
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
Hans Häcker,Vanessa Redecke,Blagoy Blagoev,Irina Kratchmarova,Li-Chung Hsu,Gang Greg Wang,Mark P. Kamps,Eyal Raz,Hermann Wagner,Georg Häcker,Matthias Mann,Michael Karin +11 more
TL;DR: It is shown that TRAF3 is essential for the induction of type I interferons (IFN) and the anti-inflammatory cytokine interleukin-10 (IL-10), but is dispensable for expression of pro- inflammatory cytokines, owing to defective IL-10 production.
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Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells
Ramunas M. Vabulas,Parviz Ahmad-Nejad,Clarissa Prazeres da Costa,Thomas Miethke,Carsten J. Kirschning,Hans Häcker,Hermann Wagner +6 more
TL;DR: To understand the proinflammatory nature of HSP, signaling induced by human and chlamydial HSP60 is analyzed and revealed that adjuvanticity of H SP60 operates similar to that of classical pathogen-derived ligands.
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Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments.
TL;DR: The need to characterize individual TLR at the very beginning of signal initiation in order to understand their diverse biological functions is stressed.