H
Hendrik Luesch
Researcher at University of Florida
Publications - 217
Citations - 8660
Hendrik Luesch is an academic researcher from University of Florida. The author has contributed to research in topics: Lyngbya & Cancer. The author has an hindex of 51, co-authored 195 publications receiving 7440 citations. Previous affiliations of Hendrik Luesch include Agency for Science, Technology and Research & Genomics Institute of the Novartis Research Foundation.
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Journal ArticleDOI
Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.
TL;DR: A novel cytotoxic cyclodepsipeptide isolated from the marine cyanobacterium Symploca sp.
Journal ArticleDOI
Marine natural products: a new wave of drugs?
Rana Montaser,Hendrik Luesch +1 more
TL;DR: This work illustrates the high degree of innovation in the field of marine natural products, which in its view will lead to a new wave of drugs that flow into the market and pharmacies in the future.
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Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula.
TL;DR: Apratoxin A (1), a potent cytotoxin with a novel skeleton, has been isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont; however, it was only marginally active in vivo against a colon tumor and ineffective against a mammary tumor.
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Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.
TL;DR: The potent antitumor agent dolastatin 10 (1) was originally isolated from the sea hare Dolabella auricularia, and it is reported its isolation from the marine cyanobacterium Symploca sp.
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Total synthesis and molecular target of largazole, a histone deacetylase inhibitor.
TL;DR: Full details of the concise and convergent synthesis of largazole, its extension to the preparation of a series of key analogues, and the molecular target and pharmacophore of largzole are described.