Marine natural products: a new wave of drugs?
Rana Montaser,Hendrik Luesch +1 more
TLDR
This work illustrates the high degree of innovation in the field of marine natural products, which in its view will lead to a new wave of drugs that flow into the market and pharmacies in the future.Abstract:
The largely unexplored marine world that presumably harbors the most biodiversity may be the vastest resource to discover novel ‘validated’ structures with novel modes of action that cover biologically relevant chemical space. Several challenges, including the supply problem and target identification, need to be met for successful drug development of these often complex molecules; however, approaches are available to overcome the hurdles. Advances in technologies such as sampling strategies, nanoscale NMR for structure determination, total chemical synthesis, fermentation and biotechnology are all crucial to the success of marine natural products as drug leads. We illustrate the high degree of innovation in the field of marine natural products, which in our view will lead to a new wave of drugs that flow into the market and pharmacies in the future.read more
Citations
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Journal ArticleDOI
Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Journal ArticleDOI
Marketed marine natural products in the pharmaceutical and cosmeceutical industries: tips for success.
TL;DR: The paths of marine natural products discovery and development are outlined, with a special focus on the compounds that successfully reached the market and particularly looking at the approaches tackled by the pharmaceutical and cosmetic companies that succeeded in marketing those products.
Journal ArticleDOI
Luteolin, a flavonoid, as an anticancer agent: A review.
Muhammad Imran,Abdur Rauf,Tareq Abu-Izneid,Muhammad Nadeem,Mohammad Ali Shariati,Imtiaz Ali Khan,Ali Imran,Ilkay Erdogan Orhan,Muhammad Rizwan,Muhammad Atif,Tanweer Aslam Gondal,Mohammad S. Mubarak +11 more
TL;DR: The present review article summarizes the progress of recent research on luteolin against several human cancers.
Journal ArticleDOI
Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action
TL;DR: The peer-reviewed marine pharmacology literature from 2009 to 2011 is presented in this review, following the format used in the 1998–2008 reviews, and the pharmacology of structurally-characterized compounds isolated from marine animals, algae, fungi and bacteria is discussed in a comprehensive manner.
Journal ArticleDOI
Marine Peptides: Bioactivities and Applications.
TL;DR: This review highlights the recent research in marine peptides and the trends and prospects for the future, with special emphasis on nutraceutical and pharmaceutical development into marketed products.
References
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Journal ArticleDOI
Natural Products as Sources of New Drugs over the Last 25 Years
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003 and is able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame.
Journal ArticleDOI
Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Journal ArticleDOI
Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.
Feling Robert H R,Greg O. Buchanan,Tracy J. Mincer,Christopher A. Kauffman,Paul R. Jensen,William Fenical +5 more
TL;DR: The ocean is an overlooked habitat from which to isolate important microorganisms, and the rate of discovery of new biologically active compounds from common soil actino-mycetes has been falling.
Journal ArticleDOI
The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families.
Shibu Yooseph,Granger G. Sutton,Douglas B. Rusch,Aaron L. Halpern,Shannon J. Williamson,Karin A. Remington,Jonathan A. Eisen,Jonathan A. Eisen,Karla B. Heidelberg,Gerard Manning,Weizhong Li,Lukasz Jaroszewski,Piotr Cieplak,Christopher S. Miller,Huiying Li,Susan T. Mashiyama,Marcin P. Joachimiak,Christopher van Belle,John-Marc Chandonia,John-Marc Chandonia,David A W Soergel,Yufeng Zhai,Kannan Natarajan,Shaun W. Lee,Benjamin J. Raphael,Vineet Bafna,Robert Friedman,Steven E. Brenner,Adam Godzik,David Eisenberg,Jack E. Dixon,Susan S. Taylor,Robert L. Strausberg,Marvin Frazier,J. Craig Venter +34 more
TL;DR: This work used sequence similarity clustering to explore proteins with a comprehensive dataset consisting of sequences from available databases together with 6.12 million proteins predicted from an assembly of 7.7 million Global Ocean Sampling sequences to add a great deal of diversity to known protein families and shed light on their evolution.
Journal ArticleDOI
Developing a new resource for drug discovery: marine actinomycete bacteria
William Fenical,Paul R. Jensen +1 more
TL;DR: The continued development of improved cultivation methods and technologies for accessing deep-sea environments promises to provide access to this significant new source of chemical diversity.