H
Henry F. McFarland
Researcher at National Institutes of Health
Publications - 308
Citations - 37629
Henry F. McFarland is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Multiple sclerosis & Myelin basic protein. The author has an hindex of 84, co-authored 307 publications receiving 36407 citations. Previous affiliations of Henry F. McFarland include Torrey Pines Institute for Molecular Studies & Government of the United States of America.
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Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
TL;DR: The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.
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Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria".
Chris H. Polman,Stephen C. Reingold,Gilles Edan,Massimo Filippi,Hans-Peter Hartung,Ludwig Kappos,Fred D. Lublin,Luanne M. Metz,Henry F. McFarland,Paul O'Connor,Magnhild Sandberg-Wollheim,Alan J. Thompson,Brian G. Weinshenker,Jerry S. Wolinsky +13 more
TL;DR: New evidence and consensus now strengthen the role of these criteria in the multiple sclerosis diagnostic workup to demonstrate dissemination of lesions in time, to clarify the use of spinal cord lesions, and to simplify diagnosis of primary progressive disease.
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Immunological aspects of demyelinating diseases
TL;DR: Recent research in MS has been focused on the characterization of cellular immune responses against myelin components and the results of these studies are reviewed and the potential implications for the pathogenesis and future therapy of MS are examined.
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Multiple sclerosis: a complicated picture of autoimmunity.
Henry F. McFarland,Roland Martin +1 more
TL;DR: Recent findings obtained with both animal models and patients with multiple sclerosis indicate involvement of a T helper cell with a TH-17 phenotype, in contrast to previous data indicating that T helper type 1 cells are critical.
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Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand.
Bibiana Bielekova,Bonnie Goodwin,Nancy Richert,Irene Cortese,Takayuki Kondo,Ghazaleh Afshar,Bruno Gran,Joan M. Eaton,Jack P. Antel,Joseph A. Frank,Henry F. McFarland,Roland Martin +11 more
TL;DR: Three patients developed exacerbations of multiple sclerosis, and in two this could be linked to altered peptide ligand treatment by immunological studies demonstrating the encephalitogenic potential of the myelin basic protein peptide in a subgroup of patients, which raise important considerations for the use of specific immunotherapies in general.