H
Heyu Ni
Researcher at University of Toronto
Publications - 167
Citations - 7908
Heyu Ni is an academic researcher from University of Toronto. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 46, co-authored 158 publications receiving 6724 citations. Previous affiliations of Heyu Ni include University of Manitoba & Brigham and Women's Hospital.
Papers
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Journal ArticleDOI
Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen
Heyu Ni,Cécile V. Denis,Sangeetha Subbarao,Jay L. Degen,Thomas N. Sato,Richard O. Hynes,Denisa D. Wagner +6 more
TL;DR: Surprisingly, mice deficient in both vWF and Fg successfully formed thrombi with properties characteristic of both mutations, leading to vessel occlusion in the majority of vessels.
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Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo
Rukhsana Aslam,Edwin R. Speck,Michael Kim,Andrew R. Crow,K. W. Annie Bang,Frederick P. Nestel,Heyu Ni,Alan H. Lazarus,John Freedman,John W. Semple +9 more
TL;DR: The results suggest that platelets express various TLRs and that the functional significance of one of these, TLR4, appears to be a role in the modulation of LPS-induced thrombocytopenia and TNF-alpha production, and implicates platelets as important mediators of innate immune responses against invading microorganisms.
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Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
June Li,Dianne E. van der Wal,Guangheng Zhu,Miao Xu,Issaka Yougbaré,Li Ma,Brian Vadasz,Naadiya Carrim,Renata Grozovsky,Min Ruan,Lingyan Zhu,Qingshu Zeng,Lili Tao,Zhimin Zhai,Jun Peng,Ming Hou,Valery Leytin,John Freedman,Karin M. Hoffmeister,Heyu Ni +19 more
TL;DR: Light is shed on Fc-independent cytopenias, designating desialylation as a potential diagnostic biomarker and therapeutic target in the treatment of refractory ITP.
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Plasma fibronectin promotes thrombus growth and stability in injured arterioles
Heyu Ni,Peter S.T. Yuen,Jessie M. Papalia,Jane E. Trevithick,Takao Sakai,Reinhard Fässler,Richard O. Hynes,Denisa D. Wagner +7 more
TL;DR: It is concluded that FN plays a significant role in thrombus initiation, growth, and stability at arterial shear rates and that deficiency in each of the three platelet ligands has its own specific impact on platelet plug formation.
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Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond
Xiaohong Ruby Xu,Dan Zhang,Brigitta Elaine Oswald,Naadiya Carrim,Xiaozhong Wang,Yan Hou,Qing Zhang,Christopher Lavalle,Thomas McKeown,Alexandra H. Marshall,Heyu Ni +10 more
TL;DR: Recent studies demonstrated that fibrinogen-independent platelet aggregation occurs in both gene deficient animals and human patients under physiological and pathological conditions, which indicates that other unidentified platelet ligands may play important roles in thrombosis and might be novel antithrombotic targets.