G
Guangheng Zhu
Researcher at St. Michael's GAA, Sligo
Publications - 38
Citations - 1520
Guangheng Zhu is an academic researcher from St. Michael's GAA, Sligo. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 18, co-authored 35 publications receiving 1256 citations. Previous affiliations of Guangheng Zhu include St. Michael's Hospital & University of Toronto.
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Journal ArticleDOI
Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
June Li,Dianne E. van der Wal,Guangheng Zhu,Miao Xu,Issaka Yougbaré,Li Ma,Brian Vadasz,Naadiya Carrim,Renata Grozovsky,Min Ruan,Lingyan Zhu,Qingshu Zeng,Lili Tao,Zhimin Zhai,Jun Peng,Ming Hou,Valery Leytin,John Freedman,Karin M. Hoffmeister,Heyu Ni +19 more
TL;DR: Light is shed on Fc-independent cytopenias, designating desialylation as a potential diagnostic biomarker and therapeutic target in the treatment of refractory ITP.
Journal ArticleDOI
Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries
Conglei Li,June Li,Yan-Yan Li,Yan-Yan Li,Sean Lang,Sean Lang,Issaka Yougbaré,Guangheng Zhu,Pingguo Chen,Pingguo Chen,Heyu Ni +10 more
TL;DR: New data suggest that platelets are important immune cells and may contribute to innate and adaptive immunity under both physiological and pathological conditions.
Journal ArticleDOI
Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor.
Adili Reheman,Adili Reheman,Hong Yang,Hong Yang,Hong Yang,Guangheng Zhu,Wuxun Jin,Feng He,Christopher M. Spring,Xufang Bai,Xufang Bai,Peter L. Gross,Peter L. Gross,John Freedman,John Freedman,Heyu Ni +15 more
TL;DR: It is shown that thrombogenesis in TKO mice was enhanced in both FeCl(3)-injured mesenteric arterioles and laser-injured cremaster arteriols and that soluble pFn is probably an important inhibitory factor for platelet aggregation.
Journal ArticleDOI
Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo
Hong Yang,Adili Reheman,Pingguo Chen,Guangheng Zhu,Richard O. Hynes,Jane E. Freedman,Denisa D. Wagner,Heyu Ni,Heyu Ni +8 more
TL;DR: β3 integrin, thrombin, and Ca2+ play critical roles in this Fg/VWF‐independent aggregation, and both plasma and platelet granule proteins contribute to this process.
Journal ArticleDOI
Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage
Issaka Yougbaré,Sean Lang,Hong Yang,Pingguo Chen,Xu Zhao,Wei-She Tai,Darko Zdravic,Brian Vadasz,Conglei Li,Siavash Piran,Alexandra H. Marshall,Guangheng Zhu,Heidi Tiller,Mette Kjaer Killie,Shelley R. Boyd,Howard Leong-Poi,Xiao-Yan Wen,Bjørn Skogen,S. Lee Adamson,John Freedman,Heyu Ni +20 more
TL;DR: The data suggest that fetal hemostasis is distinct and that impairment of angiogenesis rather than thrombocytopenia likely causes FNAIT-associated ICH, and indicates that maternal IVIG therapy can effectively prevent this devastating disorder.