Hideo Shimizu

TL;DR: It is suggested that PEBP2αA and ETS1 cooperate in vivo to regulate expression of the opn gene in the skeletal tissue and the specific spatial arrangement of both sites and direct interaction between PEBP1 and Ets1, were essential for promoter function.

TL;DR: Overall, Ang II accelerates osteoporosis by activating osteoclasts via RANKL induction, and blockade of Ang II might become a novel therapeutic approach to prevent osteopOrosis in hypertensive patients.

TL;DR: The factors and cellular pathways/processes that are known to regulate low-grade persistent inflammation in aging and age-related disease are summarized.

TL;DR: In this article, the role of RANK ligand and osteoprotegerin in vascular calcification was investigated in postmenopausal women with estrogen deficiency and showed that RANKL ligand induced calcification inducer bone morphogenetic protein-2 and decreased the calcification inhibitor matrix Gla protein (MGP) in human aortic smooth muscle cells.

TL;DR: It is demonstrated that HGF stimulated the expression of MMP-1, VEGF, HGF itself, and c-met in human endothelial cells and vascular smooth muscle cells and provides new information about the mechanisms of angiogenesis.