Hiroshi Miyashita

TL;DR: The combination of olmesartan and azelnidipine had a more beneficial effect on central systolic BP and arterial stiffness than the combination of oleochemicals and hydrochlorothiazide, despite the lack of a significant difference in brachial systolics BP reduction between the 2 treatments.

TL;DR: In vitro analysis revealed that IL-10 significantly inhibited excessive proliferation of cultured human PA smooth muscle cells treated with transforming growth factor-β1 or the heme oxygenase inhibitor tin protoporphyrin IX, which strongly prevents PA remodeling.

TL;DR: It is concluded that the conductance catheter method is useful for the assessment of the ESPVR of the in situ rat left ventricle and that the ESP VR displays contractility-dependent curvilinearity.

TL;DR: If central and peripheral pressure calibrations are equivalent, two major methods to estimate CBP—those based on generalized pressure transfer function or radial late systolic pressure—may be comparable in their accuracy of CBP parameter estimation.

TL;DR: This study demonstrates that AAV-mediated VEGF gene transfer into rat skeletal muscles is efficient and stable without ectopic expression and stimulates angiogenesis and thereby improves blood flow in a rat hindlimb ischemia model, and suggests that A AV- mediated VEGf gene transfer may be useful for treatment of ischemic diseases.