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Ignacio A. Romero
Researcher at Open University
Publications - 198
Citations - 13680
Ignacio A. Romero is an academic researcher from Open University. The author has contributed to research in topics: Blood–brain barrier & Endothelial stem cell. The author has an hindex of 59, co-authored 178 publications receiving 11819 citations. Previous affiliations of Ignacio A. Romero include University College London & King's College London.
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Journal ArticleDOI
Blood-brain barrier-specific properties of a human adult brain endothelial cell line
Babette B. Weksler,E. A. Subileau,N. Perrière,Pierre Charneau,Karen Holloway,Mathilde Leveque,H. Tricoire-Leignel,A. Nicotra,Sandrine Bourdoulous,Patric Turowski,David Male,Françoise Roux,John Greenwood,Ignacio A. Romero,P.O. Couraud +14 more
TL;DR: In this article, normal human brain endothelial cells were transduced by lentiviral vectors incorporating human telomerase or SV40 T antigen, and one was selected for expression of normal endothelial markers, including CD31, VE cadherin, and von Willebrand factor.
Journal ArticleDOI
In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use
Hans Christian Cederberg Helms,N. Joan Abbott,Malgorzata Burek,Roméo Cecchelli,Pierre Olivier Couraud,Mária A. Deli,Carola Förster,H.-J. Galla,Ignacio A. Romero,Eric V. Shusta,Matthew J. Stebbins,Elodie Vandenhaute,Babette B. Weksler,Birger Brodin +13 more
TL;DR: A review of established in vitro blood-brain barrier models with a focus on their validation regarding a set of well-established bloodbrain barrier characteristics is given in this paper, with an overview of the advantages and drawbacks of the different models described.
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The hCMEC/D3 cell line as a model of the human blood brain barrier
Babette B. Weksler,Ignacio A. Romero,Pierre-Olivier Couraud,Pierre-Olivier Couraud,Pierre-Olivier Couraud +4 more
TL;DR: The suitability of this brain microvascular endothelial cell line hCMEC/D3 as a human BBB model for pathogenic and drug transport studies is reviewed and critically considers its advantages and limitations.
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Transporting therapeutics across the blood-brain barrier
N. Joan Abbott,Ignacio A. Romero +1 more
TL;DR: The properties of this barrier that complicate drug delivery to the brain, and some of the most hopeful strategies for overcoming or bypassing the barrier in humans are reviewed.
Journal ArticleDOI
BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
L. M. Griep,Floor Wolbers,B. de Wagenaar,P.M. ter Braak,Babette B. Weksler,Babette B. Weksler,Ignacio A. Romero,P.O. Couraud,I. Vermes,A. D. van der Meer,A. van den Berg +10 more
TL;DR: The smallest model of the blood-brain barrier yet is presented, using a microfluidic chip, and the immortalized human brain endothelial cell line hCMEC/D3, which is very well suited to study barrier function and evaluate drug passage to finally gain more insight into the treatment of neurodegenerative diseases.