J
J. S. Malik Peiris
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 265
Citations - 29475
J. S. Malik Peiris is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Influenza A virus & Influenza A virus subtype H5N1. The author has an hindex of 77, co-authored 252 publications receiving 25663 citations. Previous affiliations of J. S. Malik Peiris include Shantou University & Queen Mary University of London.
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Journal ArticleDOI
Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic.
Gavin J. D. Smith,Dhanasekaran Vijaykrishna,Justin Bahl,Samantha Lycett,Michael Worobey,Oliver G. Pybus,Siu Kit Ma,CL Cheung,Jayna Raghwani,Samir Bhatt,J. S. Malik Peiris,Yi Guan,Andrew Rambaut +12 more
TL;DR: It is shown that the new swine-origin influenza A (H1N1) virus emerged in Mexico and the United States was derived from several viruses circulating in swine, and that the initial transmission to humans occurred several months before recognition of the outbreak.
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Respiratory virus shedding in exhaled breath and efficacy of face masks.
Nancy H. L. Leung,Daniel K.W. Chu,Eunice Y.C. Shiu,Kwok-Hung Chan,James J. McDevitt,Benien J.P. Hau,Benien J.P. Hau,Hui-Ling Yen,Yuguo Li,Dennis K. M. Ip,J. S. Malik Peiris,WH Seto,WH Seto,Gabriel M. Leung,Donald K. Milton,Benjamin J. Cowling +15 more
TL;DR: A study of 246 individuals with seasonal respiratory virus infections randomized to wear or not wear a surgical face mask showed that masks can significantly reduce detection of coronavirus and influenza virus in exhaled breath and may help interrupt virus transmission.
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Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
Menno D. de Jong,Cameron P. Simmons,Tran Tan Thanh,Vo Minh Hien,Gavin J. D. Smith,Tran Nguyen Bich Chau,Dang Minh Hoang,Nguyen Van Vinh Chau,Truong Huu Khanh,Vo Cong Dong,Phan Tu Qui,Bach Van Cam,Do Quang Ha,Yi Guan,J. S. Malik Peiris,Nguyen Tran Chinh,Tran Tinh Hien,Jeremy Farrar +17 more
TL;DR: The observations indicate that high viral load, and the resulting intense inflammatory responses, are central to influenza H5N1 pathogenesis and the focus of clinical management should be on preventing this intense cytokine response, by early diagnosis and effective antiviral treatment.
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Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1, from Patients with Pneumonia
Patrick C. Y. Woo,Susanna K. P. Lau,Chung-Ming Chu,Kwok-Hung Chan,Hoi-Wah Tsoi,Yi Huang,Beatrice H.L. Wong,Rosana W.S. Poon,James J. Cai,Wei-Kwang Luk,Leo L.M. Poon,Samson S. Y. Wong,Yi Guan,J. S. Malik Peiris,Kwok-Yung Yuen +14 more
TL;DR: The data support the existence of a novel group 2 coronavirus associated with pneumonia in humans, CoV-HKU1, from a 71-year-old man with pneumonia who had just returned from Shenzhen, China.
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Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury
Yumiko Imai,Keiji Kuba,Keiji Kuba,G. Greg Neely,Rubina Yaghubian-Malhami,Thomas Perkmann,Geert van Loo,Maria A. Ermolaeva,Maria A. Ermolaeva,Ruud A. W. Veldhuizen,Y.H. Connie Leung,Hongliang Wang,Haolin Liu,Yang Sun,Manolis Pasparakis,Manolis Pasparakis,Manfred Kopf,Christin Mech,Sina Bavari,J. S. Malik Peiris,Arthur S. Slutsky,Shizuo Akira,Malin Hultqvist,Rikard Holmdahl,John M. Nicholls,Chengyu Jiang,Christoph J. Binder,Josef M. Penninger +27 more
TL;DR: It is reported that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI), and it is shown that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI.