J
James A. Martin
Researcher at University of Iowa
Publications - 151
Citations - 7778
James A. Martin is an academic researcher from University of Iowa. The author has contributed to research in topics: Cartilage & Chondrocyte. The author has an hindex of 43, co-authored 148 publications receiving 6943 citations. Previous affiliations of James A. Martin include University of Iowa Hospitals and Clinics & Roy J. and Lucille A. Carver College of Medicine.
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Journal ArticleDOI
Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention
Donald D. Anderson,Susan Chubinskaya,Farshid Guilak,James A. Martin,Theodore R. Oegema,Steven A. Olson,Joseph A. Buckwalter,Joseph A. Buckwalter +7 more
TL;DR: Recent advances in understanding of the structural damage and the acute biological response following joint injury are highlighted, and important directions for future research are identified.
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Aging, articular cartilage chondrocyte senescence and osteoarthritis
TL;DR: This recent work suggests that progressive chondrocyte senescence marked by expression of thesenescence associated enzyme beta-galactosidase, erosion of chondROcyte telomere length and mitochondrial degeneration due to oxidative damage causes the age related loss of chONDrocytes function.
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The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair.
TL;DR: Findings suggest that in vivo chondrocyte senescence contributes to the age-related increase in the prevalence of osteoarthritis and decrease in the efficacy of cartilage repair and the creation of immortal cells with increased telomere length suggests that the progression of human chondROcytes toward senescences is not inevitable.
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The Potential of Human Allogeneic Juvenile Chondrocytes for Restoration of Articular Cartilage
H. Davis Adkisson,James A. Martin,Richard L. Amendola,Curt Milliman,Kelsey A. Mauch,Arbindra B. Katwal,Mitchell Seyedin,Annuziato Amendola,Philip R. Streeter,Joseph A. Buckwalter,Joseph A. Buckwalter +10 more
TL;DR: Juile human chondrocytes have greater potential to restore articular cartilage than adult cells, and may be transplanted without the fear of rejection, suggesting a new allogeneic approach to restoring articularcartilage in older individuals.
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Three-dimensional bioprinting using self-Assembling scalable scaffold-free "tissue strands" as a new bioink
Yin Yu,Kazim K. Moncal,Jianqiang Li,Weijie Peng,Iris V. Rivero,James A. Martin,Ibrahim T. Ozbolat +6 more
TL;DR: Near 8 cm-long tissue strands with rapid fusion and self-assemble capabilities are bioprinted in solid form for the first time without any need for a scaffold or a mold support or a liquid delivery medium, and facilitated native-like scale-up tissues.