J
James Scriven
Researcher at University of Cape Town
Publications - 26
Citations - 649
James Scriven is an academic researcher from University of Cape Town. The author has contributed to research in topics: Meningitis & Immune reconstitution inflammatory syndrome. The author has an hindex of 13, co-authored 23 publications receiving 554 citations. Previous affiliations of James Scriven include University of Liverpool & Liverpool School of Tropical Medicine.
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Journal ArticleDOI
Immune reconstitution inflammatory syndrome in HIV-infected patients
TL;DR: An overview of clinical and epidemiological features of HIV-associated IRIS, current understanding of pathophysiological mechanisms, available therapy, and preventive strategies, and a particular focus on three important pathogen-associated forms.
Journal ArticleDOI
Management of the Immune Reconstitution Inflammatory Syndrome
TL;DR: Clinicians should be aware of their side effects and only use them when the diagnosis of IRIS is certain, and in viral forms ofIRIS corticosteroids are generally avoided.
Journal ArticleDOI
Guideline for the prevention, diagnosis and management of cryptococcal meningitis among HIV-infected persons: 2013 update
Nelesh P. Govender,G. Meintjies,Tihana Bicanic,Halima Dawood,Tom Harrison,Joseph N Jarvis,Alan Karstaedt,D. Maartens,Kerrigan McCarthy,Helena Rabie,Ebrahim Variava,W D F Venter,David R. Boulware,Tom Chiller,David B. Meya,James Scriven +15 more
TL;DR: Govender et al. as discussed by the authors proposed a guideline for the prevention, diagnosis and management of cryptococcal meningitis among HIV-infected persons in Southern African Journal of HIV Medicine.
Journal ArticleDOI
Central Nervous System Immune Reconstitution Inflammatory Syndrome
Nathan C. Bahr,David R. Boulware,Suzaan Marais,James Scriven,James Scriven,Robert J. Wilkinson,Robert J. Wilkinson,Graeme Meintjes,Graeme Meintjes +8 more
TL;DR: A review focuses on advances in the understanding of CNS-IRIS over the past 2 years, which shows that the best supportive evidence exists for the treatment of TB- IRIS.
Journal ArticleDOI
Early ART After Cryptococcal Meningitis Is Associated With Cerebrospinal Fluid Pleocytosis and Macrophage Activation in a Multisite Randomized Trial
James Scriven,James Scriven,Joshua Rhein,Joshua Rhein,Katherine Huppler Hullsiek,Maximilian von Hohenberg,Grace Linder,Melissa A. Rolfes,Darlisha A. Williams,Darlisha A. Williams,Kabanda Taseera,David B. Meya,David B. Meya,David B. Meya,Graeme Meintjes,Graeme Meintjes,David R. Boulware +16 more
TL;DR: Early ART initiation in cryptococcal meningitis increased CSF cellular infiltrate, macrophage/microglial activation, and T helper 2 responses within the central nervous system, which suggests that increased mortality from early ART in the COAT trial was immunologically mediated.