J
Jan D. A. van Embden
Researcher at Stanford University
Publications - 26
Citations - 5444
Jan D. A. van Embden is an academic researcher from Stanford University. The author has contributed to research in topics: Mycobacterium tuberculosis & Restriction fragment length polymorphism. The author has an hindex of 24, co-authored 26 publications receiving 5083 citations.
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Journal ArticleDOI
Identification of genes that are associated with DNA repeats in prokaryotes.
TL;DR: A novel family of repetitive DNA sequences that is present among both domains of the prokaryotes but absent from eukaryotes or viruses is studied, characterized by direct repeats, varying in size from 21 to 37 bp, interspaced by similarly sized non‐repetitive sequences.
Journal ArticleDOI
Multilocus Sequence Typing Scheme for Enterococcus faecium
Wieger L. Homan,David Tribe,Simone Poznanski,Mei Li,Geoff Hogg,Emile Spalburg,Jan D. A. van Embden,Rob J. L. Willems +7 more
TL;DR: The MLST results suggest that epidemic lineages of E. faecium emerged recently worldwide, while genetic variation in both VREF and VSEF was created by longer-term recombination.
Journal ArticleDOI
Variant esp gene as a marker of a distinct genetic lineage of vancomycin-resistant Enterococcus faecium spreading in hospitals
Rob J. L. Willems,Wieger L. Homan,Janetta Top,Marga Van Santen-Verheuvel,David Tribe,Xenia Manzioros,Carlo A. J. M. Gaillard,Christina M. J. E. Vandenbroucke-Grauls,Ellen M. Mascini,Eric van Kregten,Jan D. A. van Embden,Marc J. M. Bonten +11 more
TL;DR: A specific E. faecium subpopulation genetically distinct from non-epidemic VREF isolates was found to be the cause of the hospital epidemics in all three continents and the Esp protein could be a new target for antibacterial therapy.
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Characterization of the Catalase-Peroxidase Gene (katG) and inhA Locus in Isoniazid-Resistant and -Susceptible Strains of Mycobacterium tuberculosis by Automated DNA Sequencing: Restricted Array of Mutations Associated with Drug Resistance
James M. Musser,Vivek Kapur,Diana L. Williams,Barry N. Kreiswirth,Dick van Soolingen,Jan D. A. van Embden +5 more
TL;DR: The catalase-peroxidase gene (katG) and a two-gene locus containing mutations associated with resistance to isoniazid in Mycobacterium tuberculosis were sequenced in 34 resistant and 12 susceptible strains, consistent with the hypothesis that Leu463 is the ancestral condition in M. tuberculosis.
Journal ArticleDOI
Molecular epidemiology of tuberculosis in the Netherlands: a nationwide study from 1993 through 1997.
Dick van Soolingen,Martien W. Borgdorff,Petra E. W. de Haas,M. M. G. G. Sebek,J. Veen,Mirjam Dessens,Kristin Kremer,Jan D. A. van Embden +7 more
TL;DR: The clustering percentage increased strongly with the number of isolates; taking this into account, fewer cases were clustered than has been reported in other studies.