J
Jan M. van Deursen
Researcher at Mayo Clinic
Publications - 228
Citations - 37563
Jan M. van Deursen is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Mitosis. The author has an hindex of 79, co-authored 219 publications receiving 31641 citations. Previous affiliations of Jan M. van Deursen include Max Planck Society & University Medical Center Groningen.
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Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders
Darren J. Baker,Tobias Wijshake,Tamar Tchkonia,Nathan K. LeBrasseur,Bennett G. Childs,Bart van de Sluis,James L. Kirkland,Jan M. van Deursen +7 more
TL;DR: Data indicate that cellular senescence is causally implicated in generating age-related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan.
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AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis
TL;DR: The results suggest that AML1-regulated target genes are essential for definitive hematopoiesis of all lineages, and that this defect was intrinsic to the stem cells in that AMl1-/-ES cells failed to contribute to hematocerosis in chimeric animals.
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Naturally occurring p16 Ink4a -positive cells shorten healthy lifespan
Darren J. Baker,Bennett G. Childs,Matej Durik,Melinde Wijers,Cynthia J. Sieben,Jian Zhong,Rachel A. Saltness,Karthik B. Jeganathan,Grace C Verzosa,Abdulmohammad Pezeshki,Khashayarsha Khazaie,Jordan D. Miller,Jan M. van Deursen +12 more
TL;DR: It is shown that compared to vehicle alone, AP20187 treatment extended median lifespan in both male and female mice of two distinct genetic backgrounds and the clearance of p16Ink4a-positive cells delayed tumorigenesis and attenuated age-related deterioration of several organs without apparent side effects.
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The role of senescent cells in ageing
TL;DR: A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.
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Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
Stephan Teglund,Catriona McKay,Erin G. Schuetz,Jan M. van Deursen,Dimitrios J. Stravopodis,Demin Wang,Michael Brown,Sara Bodner,Gerard Grosveld,James N. Ihle,James N. Ihle +10 more
TL;DR: The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin.