J
Jordan D. Miller
Researcher at Mayo Clinic
Publications - 110
Citations - 10757
Jordan D. Miller is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Aortic valve & Oxidative stress. The author has an hindex of 40, co-authored 108 publications receiving 8052 citations. Previous affiliations of Jordan D. Miller include University of Wisconsin-Madison & Roy J. and Lucille A. Carver College of Medicine.
Papers
More filters
Journal ArticleDOI
Naturally occurring p16 Ink4a -positive cells shorten healthy lifespan
Darren J. Baker,Bennett G. Childs,Matej Durik,Melinde Wijers,Cynthia J. Sieben,Jian Zhong,Rachel A. Saltness,Karthik B. Jeganathan,Grace C Verzosa,Abdulmohammad Pezeshki,Khashayarsha Khazaie,Jordan D. Miller,Jan M. van Deursen +12 more
TL;DR: It is shown that compared to vehicle alone, AP20187 treatment extended median lifespan in both male and female mice of two distinct genetic backgrounds and the clearance of p16Ink4a-positive cells delayed tumorigenesis and attenuated age-related deterioration of several organs without apparent side effects.
Journal ArticleDOI
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu,Tamara Tchkonia,Tamar Pirtskhalava,Adam C. Gower,Husheng Ding,Nino Giorgadze,Allyson K. Palmer,Yuji Ikeno,Yuji Ikeno,Gene B. Hubbard,Gene B. Hubbard,Marc E. Lenburg,Steven P. O'Hara,Nicholas F. LaRusso,Jordan D. Miller,Carolyn M Roos,Grace C Verzosa,Nathan K. LeBrasseur,Jonathan D. Wren,Joshua N. Farr,Sundeep Khosla,Michael B. Stout,Sara J. McGowan,Heike Fuhrmann-Stroissnigg,Aditi U. Gurkar,Jing-jing Zhao,Debora Colangelo,Akaitz Dorronsoro,Yuan Yuan Ling,Amira S. Barghouthy,Diana C. Navarro,Tokio Sano,Paul D. Robbins,Laura J. Niedernhofer,James L. Kirkland +34 more
TL;DR: The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan.
Journal ArticleDOI
Senolytics improve physical function and increase lifespan in old age
Ming Xu,Ming Xu,Tamar Pirtskhalava,Joshua N. Farr,Bettina M. Weigand,Bettina M. Weigand,Allyson K. Palmer,Megan M. Weivoda,Christina L. Inman,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Christine M Hachfeld,Daniel G. Fraser,Jennifer L Onken,Kurt O. Johnson,Grace C Verzosa,Larissa G.P. Langhi,Moritz Weigl,Nino Giorgadze,Nathan K. LeBrasseur,Jordan D. Miller,Diana Jurk,Ravinder J. Singh,David B. Allison,David B. Allison,Keisuke Ejima,Keisuke Ejima,Gene B. Hubbard,Yuji Ikeno,Yuji Ikeno,Hajrunisa Cubro,Vesna D. Garovic,Xiaonan Hou,S. John Weroha,Paul D. Robbins,Laura J. Niedernhofer,Sundeep Khosla,Tamara Tchkonia,James L. Kirkland +38 more
TL;DR: It is demonstrated that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.
Journal ArticleDOI
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Carolyn M Roos,Bin Zhang,Allyson K. Palmer,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Tamar Pirtskhalava,Nassir M. Thalji,Michael A Hagler,Diana Jurk,Leslie A. Smith,Grace Casaclang-Verzosa,Yi Zhu,Marissa J. Schafer,Tamara Tchkonia,James L. Kirkland,Jordan D. Miller +15 more
TL;DR: This is the first study to demonstrate that chronic clearance of senescent cells improves established vascular phenotypes associated with aging and chronic hypercholesterolemia, and may be a viable therapeutic intervention to reduce morbidity and mortality from cardiovascular diseases.
Journal ArticleDOI
Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
Allyson K. Palmer,Ming Xu,Ming Xu,Yi Zhu,Tamar Pirtskhalava,Megan M. Weivoda,Christine M Hachfeld,Larissa G.P. Langhi Prata,Theo H. van Dijk,Esther Verkade,Grace Casaclang-Verzosa,Kurt O. Johnson,Hajrunisa Cubro,Ewald J. Doornebal,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Diana Jurk,Diana Jurk,Michael D. Jensen,Eduardo N. Chini,Jordan D. Miller,Aleksey V. Matveyenko,Michael B. Stout,Marissa J. Schafer,Thomas A. White,La Tonya J. Hickson,Marco Demaria,Marco Demaria,Vesna D. Garovic,Joseph P. Grande,Edgar A. Arriaga,Folkert Kuipers,Thomas von Zglinicki,Nathan K. LeBrasseur,Judith Campisi,Tamar Tchkonia,James L. Kirkland +36 more
TL;DR: It is shown that reducing senescent cell burden in obese mice, either by activating drug‐inducible “suicide” genes driven by the p16Ink4a promoter or by treatment with senolytic agents, alleviates metabolic and adipose tissue dysfunction and that emerging senolytics agents hold promise for treating obesity‐related metabolic dysfunction and its complications.