J
Jane F. Lynch
Researcher at Creighton University
Publications - 292
Citations - 17258
Jane F. Lynch is an academic researcher from Creighton University. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 71, co-authored 292 publications receiving 16859 citations. Previous affiliations of Jane F. Lynch include University of Nebraska Medical Center & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review
Henry T. Lynch,Thomas C. Smyrk,Patrice Watson,Stephen J. Lanspa,Jane F. Lynch,Patrick M. Lynch,R.Jennifer Cavalieri,C. Richard Boland +7 more
TL;DR: Current knowledge is summarized, with emphasis on the manner in which this knowledge can be employed effectively for diagnosis and management of HNPCC.
Journal ArticleDOI
BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes.
Caryn Lerman,Steven A. Narod,Kevin A. Schulman,Chanita Hughes,Andres Gomez-Caminero,George E. Bonney,Karen Gold,Bruce J. Trock,David Main,Jane F. Lynch,Cecil Fulmore,Carrie Snyder,Stephen J. Lemon,Theresa Conway,Patricia N. Tonin,Gilbert M. Lenoir,Henry T. Lynch +16 more
TL;DR: Only a subset of HBOC family members are likely to request BRCA1 testing when available and rates of test use may be higher in persons of a higher socioeconomic status and those with more relatives affected with breast cancer.
Journal ArticleDOI
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
TL;DR: Because 40–60% of female patients will manifest endometrial cancer, tailored management is essential, and subtotal colectomy may be necessary, given the marked frequency of synchronous and metachronous CRC.
Journal ArticleDOI
Familial breast-ovarian cancer locus on chromosome 17q12-q23
Steven A. Narod,Jean Feunteun,Henry T. Lynch,Patrice Watson,T. Conway,Jane F. Lynch,Gilbert M. Lenoir +6 more
TL;DR: Findings suggest that the chromosomal region 17q12-q23, previously shown to contain a gene for early-onset breast cancer, is also associated with a proportion of hereditary ovarian cancers.
Journal ArticleDOI
Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). I. Clinical description of resource
Henry T. Lynch,William J. Kimberling,William A. Albano,Jane F. Lynch,Karen A. Biscone,Guy S. Schuelke,Avery A. Sandberg,Martin Lipkin,Eleanor E. Deschner,Yves B. Mikol,Robert C. Elston,Joan E. Bailey-Wilson,B. Shannon Danes +12 more
TL;DR: One documented clinical feature was a predilection for proximal versus distal colonic cancer in both CFS and HSSCC kindreds, which clarifies the need for instituting effective surveillance earlier to detect the predominantly proximal colonic cancers.