S
Stephen J. Lanspa
Researcher at Creighton University
Publications - 92
Citations - 5998
Stephen J. Lanspa is an academic researcher from Creighton University. The author has contributed to research in topics: Colorectal cancer & Lynch syndrome. The author has an hindex of 35, co-authored 91 publications receiving 5835 citations. Previous affiliations of Stephen J. Lanspa include University of Auckland & Creighton University Medical Center.
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Journal ArticleDOI
Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review
Henry T. Lynch,Thomas C. Smyrk,Patrice Watson,Stephen J. Lanspa,Jane F. Lynch,Patrick M. Lynch,R.Jennifer Cavalieri,C. Richard Boland +7 more
TL;DR: Current knowledge is summarized, with emphasis on the manner in which this knowledge can be employed effectively for diagnosis and management of HNPCC.
Journal ArticleDOI
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
TL;DR: Because 40–60% of female patients will manifest endometrial cancer, tailored management is essential, and subtotal colectomy may be necessary, given the marked frequency of synchronous and metachronous CRC.
Journal ArticleDOI
Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: A randomized trial
Ira M. Jacobson,Robert S. Brown,B. Freilich,Nezam H. Afdhal,P. Kwo,John J. Santoro,Scott Becker,Adil E. Wakil,David Pound,Eliot Godofsky,Robert Strauss,David I. Bernstein,Steven L. Flamm,Mary Pat Pauly,Pabak Mukhopadhyay,Louis Griffel,Clifford A. Brass,Martin Black,Michael Fried,David Dies,Neil Brodsky,Maurice Cerulli,Stephen Esposito,Michael G Rahmin,Jonathan David,Edward Lebovics,Raymond Kenny,Hulya Levendoglu,Lisa Ozick,Peter W Gardner,David H Berman,David Feldman,Hillel Tobias,Frank Klion,Albert D. Min,James Ehrlich,Julie E Spivack,David F. Stein,Paul Y. Kwo,Vance VanDrake,Kevin Behrle,John Serini,Howard Paul Monsour,Bhupinder S. Anand,Greg Galler,Rise Stribling,Stephen Kelly,Natarjan Bala,Thomas McDonald,Martha Ghosh,Fredric D. Gordon,Alain Ades,Myron Brand,Jeffery Cooley,Alan Epstein,Thomas Sepe,George Abraham,R. Agrawal,Mordechai Rabinovitz,Mark Smith,Fred Kilby,David Nunes,James Srour,Seth Richter,Lawton Shick,Peter Varunok,Geoffrey Zucker,Joseph Polito,Micheal Lyons,David Maccini,Geronimo Sahagun,Charles Bedard,Donald Wadland,Fredrich Loura,Arnold Levin,Terry Box,Naoky Tsai,Keith Tolman,Walid Baddoura,Micheal David Bernstein,Joseph DePasquale,Paul Bermanski,David Gabbazaideh,Gerond Lake-Bakaar,Jay Cowan,Curt Hagendom,Alan Fixelle,Raymond A. Rubin,Clive Albert,Brian K. Hudes,Mark J. Murphy,J. Lynn Cochran,Jorge Herrera,Norman Gitlin,Robert Reindollar,Jeffrey Fenyves,Kevin Dye,Thomas Noble,Larry Weprin,Michael Epstein,Robert Finkel,Natarajan Ravendhran,Michael Cox,Rudra Rai,Lou Gelrud,Ira Lobis,Michael Ryan,Vinod K. Rustgi,Mitchell L. Shiffman,James D. Lewis,Jonathan McCone,William Kaplan,David Hurwich,Donna Goldman,Rockford Yapp,Helen S. Te,Rodger Perez,Allan Weston,Fredric Regenstein,Ronald Rinker,Michael S. Dragutsky,Barry Migicovsky,Robert Herring,William A. Ross,William Lyles,Andrew Nelson,Simon Cofrancesco,John W. King,Thomas Allen,Raj Bhandari,Stuart C. Gordon,Firdous Siddiqui,Craig J. Peine,John E. Gross,John R. Lake,John Kichner,Jose Franco,James E. Nelson,James Levin,Samuel B. Ho,C. Smith,Douglas Levin,Michael Henry,Douglas D. Dalke,Jonathon Jensen,Lawrence Kim,Robert A. Levine,John S. Goff,Douglas Brouillette,Stephen J. Lanspa,Robert Manning,Stephen A. Harrison,Kenneth Diamond,M. Davis,Thuan T. Nguyen,Rvikumar Vemuru,James E. Cox,K. Ganeshappa,Harry Matossian,Edward A. Galen,Pierre Nader,K. Rajender Reddy,Gary Matusow,Steve Carlson,Jean Luc Szpakowski,Karl Esrason,Thai Van Pham,Alex D. Lee,Tim M Jenkins,Joanna Ready,Nathan Kam,Lyle Shlager,Neville R. Pimstone,Ramsey Cheung,Helen Wong,Thomas Hargrave,Diana Sylvestre,Kenneth R. DeVault,Avanish Aggarwal,Darrell Schwertner,Timothy Cavacini,Terence Reisman,Louis R. Lambiase,Donate Ricci,Mark Eisner,S. Lawrence Rothman,Michael Bloom,Arthur Berman,Paul Yudelman,Scott Wiesen,Murali Shankar,Thomas Rosenfield,John M. Vierling,David Schulman,Steven Han,Kip Lyche,Franco Felizarta,Lino Deguzman,Donald Hillebrand,Bonnie Bock,Trong Nguyen Tuan,Michael Demicco,Graham Woolf,Victor Araya,Ellen Shaw,Lawrence Stein,K. Digregorio,Carl D'Angelo,James Thornton,Steve Chen,John Jolley,Norah A. Terrault,Robert G. Gish,Ronald Wasserman,Thomas J. Layden,David H. Van Thiel,Donald M. Jensen,Mark Levstik,Ronald Pruitt,Gerald Siciliano,Bennett Cecil,Luis Marsano,Mark Jonas,Whit Knapple,Vijay Balan,Daniel Meline,Steven Palley,Leon Rigberg,David Winston,Tarek Hassanein +229 more
TL;DR: PEG‐IFN alfa‐2b plus weight‐based RBV is more effective than flat‐dose RBV, particularly in genotype 1 patients, providing equivalent efficacy across all weight groups, and RBV 1400 mg/day is appropriate for patients 105 to 125 kg.
Journal ArticleDOI
Hereditary nonpolyposis colorectal cancer - Lynch syndromes I and II
Henry T. Lynch,Stephen J. Lanspa,B. M. Boman,Thomas C. Smyrk,Patrice Watson,Jane F. Lynch,Patrick M. Lynch,Giuseppe Cristofaro,Pantaleo Bufo,A. V. Tauro,P. Mingazzini,E. DiGiulio +11 more
TL;DR: Increased knowledge about colorectal cancer etiology and carcinogenesis can be attained through the study of families prone to the Lynch syndromes, and biomarkers of acceptable sensitivity and specificity for the genotype are needed.
Journal ArticleDOI
Attenuated familial adenomatous polyposis (AFAP) a phenotypically and genotypically distinctive variant of FAP
Henry T. Lynch,Thomas C. Smyrk,Thomas R. McGinn,Stephen J. Lanspa,Jennifer Cavalieri,Jane F. Lynch,Susan Slominski-Castor,Matthew C. Cayouette,Ira Priluck,Michael C. Luce +9 more
TL;DR: A colon cancer‐prone syndrome characterized by fewer adenomas (1–100), most located in the proximal colon, and upper gastrointestinal lesions, particularly fundic gland polyps and duodenalAdenomas is described.