J
Jens-Michael Jensen
Researcher at University of Kiel
Publications - 34
Citations - 3675
Jens-Michael Jensen is an academic researcher from University of Kiel. The author has contributed to research in topics: Stratum corneum & Filaggrin. The author has an hindex of 20, co-authored 34 publications receiving 3338 citations.
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Journal ArticleDOI
The skin: an indispensable barrier
TL;DR: Changes in epidermal differentiation and lipid composition lead to a disturbed skin barrier, which allows the entry of environmental allergens, immunological reaction and inflammation in atopic dermatitis.
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Skin barrier function, epidermal proliferation and differentiation in eczema
TL;DR: Common treatment strategies for eczema include the application of lipid-based creams and ointments, which aim toward the restoration of the defective permeability barrier, thus helping to normalize proliferation and differentiation.
Journal ArticleDOI
Impaired Sphingomyelinase Activity and Epidermal Differentiation in Atopic Dermatitis
Jens-Michael Jensen,Regina Fölster-Holst,Anke Baranowsky,Michael Schunck,Supandi Winoto-Morbach,Claudia Neumann,Stefan Schütze,Ehrhardt Proksch +7 more
TL;DR: Reduction in SMase-generating ceramides and impaired differentiation are involved in the defective barrier function found in AD.
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Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier
TL;DR: It is shown that topical application of TNF after experimental injury to the SC of hairless mice (hr(-/-)) enhances barrier repair and suggests that TNF-R55 signaling pathways contribute to cutaneous permeability barrier repair through SMase-mediated generation of ceramide.
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Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis.
Jens-Michael Jensen,Stephan Pfeiffer,Magdalena Witt,Matthias Bräutigam,Claudia Neumann,Michael Weichenthal,Thomas Schwarz,Regina Fölster-Holst,Ehrhardt Proksch +8 more
TL;DR: In this paper, the effect of calcineurin inhibitor and corticosteroid on the skin barrier was investigated in 15 patients with atopic dermatitis (AD) who were treated on one upper limb with pimecrolimus and on the other with betamethasone twice daily for 3 weeks.