J
Johanna M. Brandner
Researcher at University of Hamburg
Publications - 96
Citations - 6004
Johanna M. Brandner is an academic researcher from University of Hamburg. The author has contributed to research in topics: Tight junction & Claudin. The author has an hindex of 36, co-authored 94 publications receiving 5163 citations. Previous affiliations of Johanna M. Brandner include Eppendorf (Germany).
Papers
More filters
Journal ArticleDOI
The skin: an indispensable barrier
TL;DR: Changes in epidermal differentiation and lipid composition lead to a disturbed skin barrier, which allows the entry of environmental allergens, immunological reaction and inflammation in atopic dermatitis.
Journal ArticleDOI
Organization and formation of the tight junction system in human epidermis and cultured keratinocytes.
Johanna M. Brandner,S Kief,Christine Grund,Michael Rendl,Pia Houdek,Caecilia Kuhn,Erwin Tschachler,Werner W. Franke,Ingrid Moll +8 more
TL;DR: The epidermis contains in the stratum granulosum a continuous zonula Occludens-equivalent structure with typical TJ morphology and molecular composition, characterized by colocalization of occludin, claudins and TJ plaque proteins.
Journal ArticleDOI
Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function
Robert Gruber,Peter M. Elias,Debra Crumrine,Tzu Kai Lin,Johanna M. Brandner,Jean Pierre Hachem,Richard B. Presland,Philip Fleckman,Andreas R. Janecke,Aileen Sandilands,W.H. Irwin McLean,Peter O. Fritsch,Michael Mildner,Erwin Tschachler,Matthias Schmuth +14 more
TL;DR: It is reported here that the presence of FLG mutations in Caucasians predicts dose-dependent alterations in epidermal permeability barrier function, and this results clarify how flaggrin mutations impair epidersmal permeable barrier function.
Journal ArticleDOI
Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom
Lutz Langbein,Christine Grund,Caecilia Kuhn,Silke Praetzel,Jiirgen Kartenbeck,Johanna M. Brandner,Ingrid Moll,Werner W. Franke +7 more
TL;DR: An unexpected diversity of TJ-related structures is found of which only those showing colocalization with the most restricted transmembrane TJ marker protein, occludin, are presented here.
Journal ArticleDOI
Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion.
Keiran S.M. Smalley,Patricia Brafford,Nikolas K. Haass,Johanna M. Brandner,Eric J. Brown,Meenhard Herlyn +5 more
TL;DR: Data provide the first evidence that increased ZO-1 expression in melanoma contributes to the oncogenic behavior of this tumor and further illustrate that protein products of genes can function in either a pro- or anti-oncogenic manner when expressed in different cellular contexts.