J
Joachim Degen
Researcher at University of Bonn
Publications - 42
Citations - 5066
Joachim Degen is an academic researcher from University of Bonn. The author has contributed to research in topics: Connexin & Gap junction. The author has an hindex of 29, co-authored 41 publications receiving 4749 citations.
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Journal ArticleDOI
Structural and functional diversity of connexin genes in the mouse and human genome
Klaus Willecke,Jürgen Eiberger,Joachim Degen,Dominik Eckardt,Alessandro Romualdi,Martin Güldenagel,Urban Deutsch,Goran Söhl +7 more
TL;DR: This review compares currently identified connexin genes in both the mouse and human genome and discusses the functions of gap junctions deduced from targeted mouse mutants and human genetic disorders.
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Slow Conduction and Enhanced Anisotropy Increase the Propensity for Ventricular Tachyarrhythmias in Adult Mice With Induced Deletion of Connexin43
Harold V.M. van Rijen,Dominik Eckardt,Joachim Degen,Martin Theis,Thomas Ott,Klaus Willecke,Habo J. Jongsma,Tobias Opthof,Jacques M.T. de Bakker +8 more
TL;DR: Heterozygous expression of Cx43 did not affect ventricular conduction velocity and increased dispersion of conduction and propensity for ventricular arrhythmias.
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The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain development
TL;DR: A new gap junction gene isolated from rat brain cDNA, mouse retina cDNA and mouse genomic DNA is called connexin36, since it codes for a connexIn protein of 321 amino acids corresponding to the theoretical molecular mass of 36 045 kDa (rat) and 36’084 kDa(mouse).
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Connexin 47 (Cx47)-Deficient Mice with Enhanced Green Fluorescent Protein Reporter Gene Reveal Predominant Oligodendrocytic Expression of Cx47 and Display Vacuolized Myelin in the CNS
Benjamin Odermatt,Kerstin Wellershaus,Anke Wallraff,Gerald Seifert,Joachim Degen,Carsten Euwens,Babette Fuss,Heinrich Büssow,Karl Schilling,Christian Steinhäuser,Klaus Willecke +10 more
TL;DR: Colocalization of EGFP fluorescence and immunofluorescence of cell marker proteins revealed that Cx47 was mainly expressed in oligodendrocytes in highly myelinated CNS tissues and in few calcium-binding protein S100β subunit-positive cells but not in neurons or peripheral sciatic nerve.
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Adult ceramide synthase 2 (CerS2) deficient mice exhibit myelin sheath defects, cerebellar degeneration and hepatocarcinomas
Silke Imgrund,Dieter Hartmann,Hany Farwanah,Matthias Eckhardt,Roger Sandhoff,Joachim Degen,Volkmar Gieselmann,Konrad Sandhoff,Klaus Willecke +8 more
TL;DR: The results indicate that CERS2 activity supports different biological functions: maintenance of myelin, stabilization of the cerebellar as well as renal histological architecture, and protection against hepatocarcinomas.