Jonathan M. Williams

TL;DR: Current knowledge about intestinal epithelial cell shedding, its significance in gut barrier dysfunction and host-microbial interactions, and where research in this field is directed are summarized.

TL;DR: A murine model is developed to enable investigation of the importance and regulation of pathological IEC apoptosis and cell shedding in various diseases and a significant increase in gut-to-circulation permeability was observed at 5 hours.

TL;DR: Gastric colonization with Helicobacter pylori induces diverse human pathological conditions, including superficial gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma and its precursors, and the animal models of these conditions are discussed.

TL;DR: Overall, altering dietary iron intake exacerbated DSS-induced colitis; increasing the iron content of the diet also led to changes in intestinal bacteria diversity and composition after colitis was induced with DSS.

TL;DR: Two methods of intestinal sampling at necropsy that allow systematic histological analysis of the entire intestinal tract are described, either through examination of cross sections (circumferences) by the gut bundling technique or longitudinal sections by the adapted Swiss roll technique, together with basic methods for data collection.