J
Jürgen K. Rockstroh
Researcher at University Hospital Bonn
Publications - 432
Citations - 22329
Jürgen K. Rockstroh is an academic researcher from University Hospital Bonn. The author has contributed to research in topics: Hepatitis C & Hepatitis C virus. The author has an hindex of 69, co-authored 401 publications receiving 20025 citations. Previous affiliations of Jürgen K. Rockstroh include University of Erlangen-Nuremberg & University of Copenhagen.
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Journal ArticleDOI
Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients.
Francesca J. Torriani,Maribel Rodriguez-Torres,Jürgen K. Rockstroh,Eduardo Lissen,Juan González-García,Adriano Lazzarin,Giampiero Carosi,Joe Sasadeusz,Christine Katlama,Julio S. G. Montaner,Sette H,Sharon Passe,Jean De Pamphilis,Frank Duff,Uschi Marion Schrenk,Douglas T. Dieterich +15 more
TL;DR: Among patients infected with both HIV and HCV, the combination of peginterferon alfa-2a plus ribavirin was significantly more effective than either interferonalfa- 2a plus Ribavirin or pegin terferonAlfa-3a monotherapy.
Journal ArticleDOI
Raltegravir with Optimized Background Therapy for Resistant HIV-1 Infection
Roy T. Steigbigel,David A. Cooper,Princy Kumar,Joseph E. Eron,Mauro Schechter,Martin Markowitz,Mona R. Loutfy,Jeffrey L. Lennox,Jose M. Gatell,Jürgen K. Rockstroh,Christine Katlama,Patrick Yeni,Adriano Lazzarin,Bonaventura Clotet,Jing Zhao,Joshua Chen,Desmond Ryan,Rand R. Rhodes,John A. Killar,Lucinda R. Gilde,Kim M. Strohmaier,Anne R. Meibohm,Michael D. Miller,Daria J. Hazuda,Michael L. Nessly,Mark J. DiNubile,Robin Isaacs,Bach-Yen Nguyen,Hedy Teppler +28 more
TL;DR: In HIV-infected patients with limited treatment options, raltegravir plus optimization background therapy provided better viral suppression than optimized background therapy alone for at least 48 weeks.
Journal ArticleDOI
Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans
Ulrich Salzer,Helen Chapel,A. D. B. Webster,Qiang Pan-Hammarström,Annette Schmitt-Graeff,Michael Schlesier,Hans-Hartmut Peter,Jürgen K. Rockstroh,Pascal Schneider,Alejandro A. Schäffer,Lennart Hammarström,Bodo Grimbacher +11 more
TL;DR: Heterozygosity with respect to mutations causing the amino acid substitutions S144X and C104R abrogated APRIL binding and resulted in loss of TACI function, as evidenced by impaired proliferative response to IgM-APRIL costimulation and defective class switch recombination induced by IL-10 and APRIL or BAFF.
Journal ArticleDOI
Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study
Alison Rodger,Valentina Cambiano,Tina Bruun,Pietro Vernazza,Simon Collins,Olaf Degen,Giulio Maria Corbelli,Vicente Estrada,Anna Maria Geretti,Apostolos Beloukas,Apostolos Beloukas,Dorthe Raben,Pep Coll,Andrea Antinori,Nneka Nwokolo,Armin Rieger,Jan M Prins,Anders Blaxhult,Rainer Weber,Arne Van Eeden,Norbert H. Brockmeyer,Amanda Clarke,Jorge del Romero Guerrero,François Raffi,Johannes R. Bogner,Gilles Wandeler,Jan Gerstoft,Félix Gutiérrez,Kees Brinkman,Maria Kitchen,Lars Østergaard,Agathe León,Matti Ristola,Heiko Jessen,Hans-Jürgen Stellbrink,Andrew N. Phillips,Jens D Lundgren,Patricia Cobarsi,Aroa Nieto,Michael Meulbroek,Antonia Carrillo,Jorge Saz,Jorge D.R. Guerrero,Mar Vera García,Mar Masiá,Catalina Robledano,Lorna Leal,Eva G. Redondo,Vicente Estrada,Rocio Marquez,Raquel Sandoval,Pompeyo Viciana,Nuria Espinosa,Luis F. López-Cortés,Daniel Podzamczer,Juan Tiraboschi,Sandra Morenilla,Antonio Antela,Elena Losada,Janey Sewell,Sarah Kirk,Alyson Knott,Thomas Fernandez,Mark Gompels,Louise Jennings,Lana Ward,Julie Fox,Julianne Lwanga,Ming Lee,Richard Gilson,Clifford Leen,Sheila Morris,Dan Clutterbuck,Michael Brady,David Asboe,Serge Fedele,Sarah Fidler,Norbert Brockmeyer,Anja Potthoff,Adriane Skaletz-Rorowski,Johannes Bogner,Ulrich Seybold,Julia Roider,Arne Jessen,Slobodan Ruzicic,Tim Kümmerle,Clara Lehmann,Sindy Bartel,Anja Hüfner,Jürgen K. Rockstroh,Karina Mohrmann,Christoph Boesecke,Ivanka Krznaric,Patrick Ingiliz,Christina Grube,Dominique Braun,Huldrych F. Günthard,Hansjakob Furrer,Andri Rauch,Patrick Schmid,Manuela Rasi,Denise Borso,Markus Stratmann,Oliver Caviezel,Marcel Stoeckle,Manuel Battegay,Philip E. Tarr,Vanessa Christinet,Florent Jouinot,Camille Isambert,Enos Bernasconi,Beatrice Bernasconi,Lene P. Jensen,Anne A. Bayer,Yordanos Yehdego,Ann Bach,Pia Handberg,Gitte Kronborg,Svend s. Pedersen,Nete Bülow,Bente Ramskover,Outi Debnam,Jussi Sutinen,Ronnie Ask,Bernt Hildingsson-Lundh,Katarina Westling,Eeva-Maija Frisen,Gráinne Cortney,Siobhan O'Dea,Stéphane De Wit,Coca Necsoi,Linos Vandekerckhove,Jean-Christophe Goffard,Sophie Henrard,Jan M. Prins,Hans-Henrik Nobel,Annouschka Weijsenfeld,Loek Elsenburg,Danielle Vos,Imke Hoijenga,Elisabeth Gisolf,Petra Van Bentum,Dominique Verhagen,Eric Billaud,Michel Ohayon,Daniel Gosset,Alexandre Fior,Gilles Pialoux,Pelagie Thibaut,Julie Chas,Vincent Leclercq,Vincent Pechenot,Vincent Coquelin,Christian Pradier,Sophie Breaud,Veronique Touzeau-Romer,Maria Kitchen Maria Geit,Mario Sarcletti,Martin Gisinger,Angela Oellinger,Samanta Menichetti,Teresa Bini,Cristina Mussini,Marianna Meschiari,Antonio Di Biagio,Lucia Taramasso,Benedetto Maurizio Celesia,M. Gussio,Nuno Janeiro +168 more
TL;DR: The results suggest that the risk of HIV transmission in gay couples through condomless sex when HIV viral load is suppressed is effectively zero, which supports the message of the U=U (undetectable equals untransmittable) campaign, and the benefits of early testing and treatment for HIV.
Journal ArticleDOI
Effect of antiretroviral therapy on liver-related mortality in patients with HIV and hepatitis C virus coinfection.
Naztfa Qurishi,Christina Kreuzberg,Guido Lüchters,W. Effenberger,Bernd Kupfer,Tilman Sauerbruch,Jürgen K. Rockstroh,Ulrich Spengler +7 more
TL;DR: In addition to improved overall survival, antiretroviral therapy significantly reduced long-term liver-related mortality in patients and seems to outweigh by far the associated risks of severe hepatotoxicity.