K
Kai Sen Tan
Researcher at National University of Singapore
Publications - 59
Citations - 4604
Kai Sen Tan is an academic researcher from National University of Singapore. The author has contributed to research in topics: Influenza A virus & Virus. The author has an hindex of 16, co-authored 57 publications receiving 3108 citations. Previous affiliations of Kai Sen Tan include Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.
Yan Rong Guo,Qing Dong Cao,Zhong Si Hong,Yuan Yang Tan,Shoudeng Chen,Hong Jun Jin,Kai Sen Tan,De Yun Wang,Yan Yan +8 more
TL;DR: The latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19 are summarized, and the current treatment and scientific advancements to combat the epidemic novel coronavirus are discussed.
Journal ArticleDOI
Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia.
Kim S. Robinson,Daniel Eng Thiam Teo,Kai Sen Tan,Gee Ann Toh,Hsiao Hui Ong,Chrissie Lim,Kenneth Lay,Bijin Veonice Au,Tian Sheng Lew,Justin Jang Hann Chu,Justin Jang Hann Chu,Vincent T. K. Chow,De Yun Wang,Franklin L. Zhong,Bruno Reversade +14 more
TL;DR: In this article, the authors showed that human NACHT, LRR, and PYD domains-containing protein 1 (NLRP1) is activated by 3C proteases (3Cpros) of enteroviruses, such as human rhinovirus (HRV), which directly cleaves human NLRP1 at a single site between Glu130 and Gly131.
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Viral Load of SARS-CoV-2 in Respiratory Aerosols Emitted by COVID-19 Patients while Breathing, Talking, and Singing.
Kristen K. Coleman,Douglas Jie Wen Tay,Kai Sen Tan,Sean Wei Xiang Ong,Ming Hui Koh,Yi Qing Chin,Haziq Nasir,Tze Minn Mak,Justin Jang Hann Chu,Donald K. Milton,Vincent T. K. Chow,Paul A. Tambyah,Mark I-Cheng Chen,Tham Kwok Wai +13 more
TL;DR: In this paper, the authors measured viral RNA in coarse and fine respiratory aerosols emitted by COVID-19 patients during 30 minutes of breathing, 15 minutes of talking, and 15 minutes singing.
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Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles.
Akshamal M. Gamage,Kai Sen Tan,Wharton O. Y. Chan,Jing Liu,Chee Wah Tan,Yew Kwang Ong,Mark Thong,Anand Kumar Andiappan,Danielle E. Anderson,De Yun Wang,Lin-Fa Wang +10 more
TL;DR: NECs differentiated from healthy nasal-tissue derived stem cells are established as a suitable model for the ex-vivo study of SARS-CoV-2 mediated pathogenesis, and a non-essential role for ORF8 is demonstrated in modulating host gene expression and cytokine production from infected cells.
Journal ArticleDOI
In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection.
Kai Sen Tan,Kai Sen Tan,Farzad Olfat,Meng Chee Phoon,Jung Pu Hsu,J. Howe,Ju Ee Seet,Keh Chuang Chin,Vincent T. K. Chow +8 more
TL;DR: Although the in vitro studies demonstrated the ability of viperin to restrict influenza H1N1 virus replication, the viperIn-deficient mouse model indicated that absence of vipersin enhanced neither the viral load nor pulmonary damage in the lungs of infected mice, suggesting that further investigations that exploit the antiviral mechanisms of v Viperin as prophylaxis are still warranted.