K
Katharina F. Sonnen
Researcher at Royal Netherlands Academy of Arts and Sciences
Publications - 18
Citations - 1360
Katharina F. Sonnen is an academic researcher from Royal Netherlands Academy of Arts and Sciences. The author has contributed to research in topics: Basal body & Somitogenesis. The author has an hindex of 9, co-authored 15 publications receiving 1016 citations. Previous affiliations of Katharina F. Sonnen include University of Basel & European Bioinformatics Institute.
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3D-structured illumination microscopy provides novel insight into architecture of human centrosomes.
TL;DR: This study provides novel insights into the architecture of human centrosomes and illustrates the power of super-resolution microscopy in revealing the relative localization of centriole and PCM proteins in unprecedented detail.
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Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids
Susanne C. van den Brink,Anna Alemany,Vincent van Batenburg,Naomi Moris,Marloes Blotenburg,Judith Vivié,Peter Baillie-Johnson,Jennifer Nichols,Katharina F. Sonnen,Alfonso Martinez Arias,Alexander van Oudenaarden +10 more
TL;DR: The power of gastruloids as a model system for exploring development and somitogenesis in vitro in a high-throughput manner is shown, as it can be induced to generate somites with the correct rostral–caudal patterning.
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Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.
Katharina F. Sonnen,Anna-Maria Gabryjonczyk,Eduard Anselm,York-Dieter Stierhof,Erich A. Nigg +4 more
TL;DR: The roles of two homologous mammalian proteins, Cep152 and Cep192, in the centriole recruitment of human Plk4 are explored and it is demonstrated that Cep 192 plays a key role in centrosome recruitment of both Cep 152 and Plk 4.
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Cell-cycle-regulated expression of STIL controls centriole number in human cells.
TL;DR: It is shown that STIL is recruited to nascent daughter centrioles at the onset of centriole duplication and degraded, in an APC/CCdc20–Cdh1-dependent manner, upon passage through mitosis.
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Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation
Katharina F. Sonnen,Volker M. Lauschke,Julia Uraji,Henning J. Falk,Yvonne Petersen,Maja C. Funk,Mathias Beaupeux,Paul François,Christoph A. Merten,Alexander Aulehla +9 more
TL;DR: This work develops a new experimental strategy using microfluidics-based entrainment that enables specific control of the rhythm of segmentation clock oscillations and finds that Wnt and Notch signaling are coupled at the level of their oscillation dynamics.