Kathryn E. Holt

TL;DR: Tests on both synthetic and real reads show Unicycler can assemble larger contigs with fewer misassemblies than other hybrid assemblers, even when long-read depth and accuracy are low.

TL;DR: Tests on both synthetic and real reads show Unicycler can assemble larger contigs with fewer misassemblies than other hybrid assemblers, even when long read depth and accuracy are low.

TL;DR: The current version of ONT’s Guppy basecaller performs well overall, with good accuracy and fast performance, and users should consider producing a custom model using a larger neural network and/or training data from the same species.

TL;DR: Bandage (a Bioinformatics Application for Navigating De novo Assembly Graphs Easily) is a tool for visualizing assembly graphs with connections that presents new possibilities for analyzing de novo assemblies that are not possible through investigation of contigs alone.

TL;DR: Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period, consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities.