K
Katja Dettmer
Researcher at University of Regensburg
Publications - 126
Citations - 9452
Katja Dettmer is an academic researcher from University of Regensburg. The author has contributed to research in topics: Mass spectrometry & Gas chromatography. The author has an hindex of 43, co-authored 116 publications receiving 7525 citations. Previous affiliations of Katja Dettmer include Leipzig University & University of California, Davis.
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Journal ArticleDOI
Mass spectrometry-based metabolomics.
TL;DR: This review presents an overview of the dynamically developing field of mass spectrometry-based metabolomics, a technique that analyzes all detectable analytes in a given sample with subsequent classification of samples and identification of differentially expressed metabolites, which define the sample classes.
Journal ArticleDOI
LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.
Almut Brand,Katrin Singer,Gudrun E. Koehl,Marlene Kolitzus,Gabriele Schoenhammer,Annette Thiel,Carina Matos,Christina Bruss,Sebastian Klobuch,K. Peter,K. Peter,Michael Kastenberger,Christian Bogdan,Ulrike Schleicher,Andreas Mackensen,Evelyn Ullrich,Stefan Fichtner-Feigl,Stefan Fichtner-Feigl,Rebecca Kesselring,Matthias Mack,Matthias Mack,Uwe Ritter,Maximilian Schmid,Maximilian Schmid,Christian U. Blank,Katja Dettmer,Peter J. Oefner,Petra Hoffmann,Petra Hoffmann,Stefan Walenta,E. K. Geissler,Jacques Pouysségur,Andreas Villunger,André Steven,Barbara Seliger,Stephan Schreml,Sebastian Haferkamp,Elisabeth Kohl,Sigrid Karrer,Mark Berneburg,Wolfgang Herr,Wolfgang Mueller-Klieser,Kathrin Renner,Kathrin Renner,Marina Kreutz,Marina Kreutz +45 more
TL;DR: It is shown that LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and NK cells, and is a potent inhibitor of function and survival of T andNK cells leading to tumor immune escape.
Journal ArticleDOI
Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes
Katrin Dietl,Kathrin Renner,Katja Dettmer,Birgit Timischl,Karin Eberhart,Christoph Dorn,Claus Hellerbrand,Michael Kastenberger,Leoni A. Kunz-Schughart,Peter J. Oefner,Reinhard Andreesen,Eva Gottfried,Marina Kreutz +12 more
TL;DR: The hypothesis that TNF secretion by human monocytes depends on glycolysis is supported and it is suggested that LA and acidification may be involved in the suppression of T NF secretion in the tumor environment.
Journal ArticleDOI
Adsorbent materials commonly used in air analysis for adsorptive enrichment and thermal desorption of volatile organic compounds.
Katja Dettmer,Werner Engewald +1 more
TL;DR: The requirements that an adsorbent should fulfill, and useful parameters for the selection and evaluation of an appropriate material are discussed, and the most important materials are presented considering their properties, advantages, and drawbacks.
Journal ArticleDOI
Srebp-controlled glucose metabolism is essential for NK cell functional responses
Nadine Assmann,Katie L. O’Brien,Raymond P. Donnelly,Lydia Dyck,Vanessa Zaiatz-Bittencourt,Róisín M. Loftus,Paul Heinrich,Peter J. Oefner,Lydia Lynch,Clair M. Gardiner,Katja Dettmer,David K. Finlay +11 more
TL;DR: It is demonstrated that an essential role for Srebp transcription factors in cytokine-induced metabolic reprogramming of NK cells that was independent of their conventional role in the control of lipid synthesis is demonstrated.