P
Pavel A. Aronov
Researcher at University of California, Davis
Publications - 25
Citations - 3859
Pavel A. Aronov is an academic researcher from University of California, Davis. The author has contributed to research in topics: Epoxide hydrolase 2 & Caspase 3. The author has an hindex of 16, co-authored 25 publications receiving 3410 citations. Previous affiliations of Pavel A. Aronov include VA Palo Alto Healthcare System & Stanford University.
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Journal ArticleDOI
Mass spectrometry-based metabolomics.
TL;DR: This review presents an overview of the dynamically developing field of mass spectrometry-based metabolomics, a technique that analyzes all detectable analytes in a given sample with subsequent classification of samples and identification of differentially expressed metabolites, which define the sample classes.
Journal ArticleDOI
Colonic Contribution to Uremic Solutes
Pavel A. Aronov,Frank J.-G. Luo,Natalie S. Plummer,Zhe Quan,Susan Holmes,Thomas H. Hostetter,Timothy W. Meyer +6 more
TL;DR: Compounds with accurate mass values matching most of the colon-derived solutes could not be found in standard metabolomic databases, suggesting that colonic microbes may produce an important portion of uremic solutes.
Journal ArticleDOI
A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice
Angela Marcobal,Purna C. Kashyap,Purna C. Kashyap,Tyrrell A. Nelson,Pavel A. Aronov,Mohamed S. Donia,Alfred M. Spormann,Michael A. Fischbach,Justin L. Sonnenburg +8 more
TL;DR: It is shown that simplified communities can drive major changes in the host metabolomic profile, and is demonstrated that metabolomics constitutes a powerful avenue for functional characterization of the intestinal microbiota and its interaction with the host.
Journal ArticleDOI
Urine metabolomics analysis for kidney cancer detection and biomarker discovery.
Kyoungmi Kim,Pavel A. Aronov,Stanislav O. Zakharkin,Danielle E. Anderson,Bertrand Perroud,Ian M. Thompson,Robert H. Weiss +6 more
TL;DR: Urine metabolomics analysis has potential to lead to a diagnostic assay for RCC, and there is little difference in the urinary metabolomic profile in a cohort of pre- and postnephrectomy (partial or radical) renal cell carcinoma patients, suggesting that metabolic changes associated with RCC persist after removal of the primary tumor.
Journal ArticleDOI
Regulation of Ceramide Biosynthesis by TOR Complex 2
Sofia Aronova,Karen Wedaman,Pavel A. Aronov,Kristin Fontes,Karmela Ramos,Bruce D. Hammock,Ted Powers +6 more
TL;DR: It is demonstrated that yeast cells deficient in TORC2 activity are impaired for de novo ceramide biosynthesis both in vivo and in vitro, and a model whereinTORC2 signaling is coupled with LCB levels to control Ypk2 activity and, ultimately, regulate ceramide formation is suggested.