K
Kenneth Ndebele
Researcher at Jackson State University
Publications - 18
Citations - 705
Kenneth Ndebele is an academic researcher from Jackson State University. The author has contributed to research in topics: Apoptosis & Arsenic trioxide. The author has an hindex of 13, co-authored 17 publications receiving 591 citations. Previous affiliations of Kenneth Ndebele include Beth Israel Deaconess Medical Center.
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The Renin-Angiotensin-Aldosterone System in Vascular Inflammation and Remodeling
TL;DR: Evidence shows that inhibition of RAAS positively influences vascular remodeling thus improving CVD outcomes, and the need to rethink and rediscover new RAAS inhibitors is shared.
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Evaluation of Arsenic Trioxide Potential for Lung Cancer Treatment: Assessment of Apoptotic Mechanisms and Oxidative Damage
TL;DR: Results indicate that ATO is cytotoxic to lung cancer cells and its bioactivity is associated with oxidative damage, changes in cellular morphology, and apoptosis.
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Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Alters Mitochondrial Membrane Lipids
Ferry Sandra,Mauro Degli Esposti,Kenneth Ndebele,Philimon Gona,David Knight,Magnus Rosenquist,Roya Khosravi-Far +6 more
TL;DR: It is reported that TRAIL signaling induces an alteration in mitochondrial membrane lipids, particularly cardiolipin, which occurs independently of caspase activation and primes mitochondrial membranes to the proapoptotic action of Bid.
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Arsenic Trioxide Modulates DNA Synthesis and Apoptosis in Lung Carcinoma Cells.
TL;DR: Evaluating the effects of arsenic trioxide on DNA synthesis and whether arsenic-induced apoptosis is mediated via caspase activation, p38 mitogen–activated protein kinase (MAPK), and cell cycle arrest revealed a dose-related cytotoxic response at high levels of exposure.
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A Peroxidase Peroxiredoxin 1-Specific Redox Regulation of the Novel FOXO3 microRNA Target let-7
Barbara L. Hopkins,Monica J. S. Nadler,John J. Skoko,Thierry Bertomeu,Andrea Pelosi,Parisa Mousavi Shafaei,Kevin M. Levine,Anja Schempf,Bodvael Pennarun,Bo Yang,Dipak Datta,Octavian Bucur,Octavian Bucur,Kenneth Ndebele,Steffi Oesterreich,Da Yang,Maria Giulia Rizzo,Roya Khosravi-Far,Carola A. Neumann +18 more
TL;DR: The existence of an H2O2-sensitive PRDX1-FOXO3 signaling axis that fine tunes FOXO3 activity toward the transcription of gene targets in response to oxidative stress is ascertained.