Kenneth T. Wheeler

TL;DR: There is a critical need to investigate the microanatomic and functional effects of radiation in various brain regions as well as their integration at clinically relevant doses and schedules.

TL;DR: The use of a novel photoaffinity probe, WC-21, to identify the putative sigma-2 receptor binding site as PGRMC1 should stimulate the development of unique imaging agents and cancer therapeutics that target the sigma -2 receptor/PGRMC1 complex.

TL;DR: The agreement between the solid tumour and tissue culture data indicates that the expression of σ2receptors may be a reliable biomarker of the proliferative status of solid tumours and radioligands with both high affinity and high selectivity for ρ2receptor may have the potential to non-invasively assess the proliferatives status of humansolid tumours using imaging techniques such as positron emission tomography or single-photon emission computerized tomography.

TL;DR: The results of this study suggest that the release of bases originating from irradiation of the hydration water is obtained predominantly by charge transfer from the direct ionization of the first 12-15 water molecules of the primary hydration layer and by the attack of hydroxyl radicals generated in the outer, more loosely bound water molecules.

TL;DR: Data suggest that ligands labeled with positron-emitting or single photon-emmitting radionuclides, which selectively bind sigma 2 receptors, have the potential to noninvasively assess the proliferative status of human breast tumors.