M
Michael D. Chan
Researcher at Wake Forest University
Publications - 207
Citations - 6451
Michael D. Chan is an academic researcher from Wake Forest University. The author has contributed to research in topics: Radiosurgery & Brain metastasis. The author has an hindex of 38, co-authored 193 publications receiving 4851 citations. Previous affiliations of Michael D. Chan include University of Oklahoma Health Sciences Center & Tufts University.
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Journal ArticleDOI
Radiation-induced brain injury: A review
Dana Greene-Schloesser,Mike E. Robbins,Ann M. Peiffer,Edward G. Shaw,Kenneth T. Wheeler,Michael D. Chan +5 more
TL;DR: There is a critical need to investigate the microanatomic and functional effects of radiation in various brain regions as well as their integration at clinically relevant doses and schedules.
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Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
TL;DR: The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity and the current landscape of the Shh-SMO-GLI pathway inhibitors including those in preclinical studies and clinical trials is detailed.
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Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis
Fei Xing,Yin Liu,Shih-Ying Wu,Kerui Wu,Sambad Sharma,Yin-Yuan Mo,Jiamei Feng,Stephanie Sanders,Guangxu Jin,Ravi Singh,Pierre-Alexandre Vidi,Abhishek Tyagi,Michael D. Chan,Jimmy Ruiz,Waldemar Debinski,Boris Pasche,Hui-Wen Lo,Linda J. Metheny-Barlow,Ralph B. D'Agostino,Kounosuke Watabe +19 more
TL;DR: Mechanisms of how loss of the lncRNA XIST promotes brain metastasis in breast cancer are described and fludarabine is identified as a potential therapeutic agent that specifically eliminates XISTlow tumor cells in the brain.
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MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia.
Elizabeth H. Aylward,Qiang Li,Nancy A. Honeycutt,Andrew C. Warren,Margaret B. Pulsifer,Patrick E. Barta,Michael D. Chan,Paige D. Smith,Matthew Jerram,Godfrey D. Pearlson +9 more
TL;DR: Hippocampal volume, while disproportionately small for brain size in individuals with Down's syndrome, remains fairly constant through the fifth decade of life in those without dementia.
Journal ArticleDOI
Donepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial
Stephen R. Rapp,L. Doug Case,Ann M. Peiffer,Michelle M. Naughton,Michael D. Chan,Volker W. Stieber,Dennis F. Moore,Steven Charles Falchuk,James Piephoff,William Jeffery Edenfield,Jeffrey K. Giguere,Monica Loghin,Edward G. Shaw +12 more
TL;DR: Treatment with donepezil did not significantly improve the overall composite score, but it did result in modest improvements in several cognitive functions, especially among patients with greater pretreatment impairments.