K
Kevin Schoemaker
Publications - 1
Citations - 1127
Kevin Schoemaker is an academic researcher. The author has contributed to research in topics: Kinase & In vivo. The author has an hindex of 1, co-authored 1 publications receiving 1079 citations.
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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
Sauveur-Michel Maira,Frédéric Stauffer,Josef Brueggen,Pascal Furet,Christian Schnell,Christine Fritsch,Saskia M. Brachmann,Patrick Chène,Alain De Pover,Kevin Schoemaker,Doriano Fabbro,Daniela Gabriel,Marjo Simonen,Leon Murphy,Peter Finan,William R. Sellers,Carlos Garcia-Echeverria +16 more
TL;DR: The preclinical data show that NVP-BEZ235 is a potent dual PI3K/mTOR modulator with favorable pharmaceutical properties, and the compound was well tolerated, displayed disease stasis when administered orally, and enhanced the efficacy of other anticancer agents when used in in vivo combination studies.