P
Patrick Chène
Researcher at Novartis
Publications - 115
Citations - 6892
Patrick Chène is an academic researcher from Novartis. The author has contributed to research in topics: Mutant & Hippo signaling pathway. The author has an hindex of 34, co-authored 106 publications receiving 6290 citations. Previous affiliations of Patrick Chène include University Hospital of Lausanne.
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Journal ArticleDOI
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
Sauveur-Michel Maira,Frédéric Stauffer,Josef Brueggen,Pascal Furet,Christian Schnell,Christine Fritsch,Saskia M. Brachmann,Patrick Chène,Alain De Pover,Kevin Schoemaker,Doriano Fabbro,Daniela Gabriel,Marjo Simonen,Leon Murphy,Peter Finan,William R. Sellers,Carlos Garcia-Echeverria +16 more
TL;DR: The preclinical data show that NVP-BEZ235 is a potent dual PI3K/mTOR modulator with favorable pharmaceutical properties, and the compound was well tolerated, displayed disease stasis when administered orally, and enhanced the efficacy of other anticancer agents when used in in vivo combination studies.
Journal ArticleDOI
Inhibiting the p53-MDM2 interaction: an important target for cancer therapy.
TL;DR: In this study, inhibiting the p53–MDM2 interaction with synthetic molecules should lead to p53-mediated cell-cycle arrest or apoptosis in p 53-positive stressed cells.
Journal ArticleDOI
Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
Sauveur-Michel Maira,Sabina Pecchi,Alan Huang,Matthew Burger,Mark Knapp,Dario Sterker,Christian Schnell,Daniel Guthy,Tobi Nagel,Marion Wiesmann,Saskia M. Brachmann,Christine Fritsch,Marion Dorsch,Patrick Chène,Kevin Shoemaker,Alain De Pover,Daniel Menezes,Georg Martiny-Baron,Doriano Fabbro,Christine D. Wilson,Robert Schlegel,Francesco Hofmann,Carlos Garcia-Echeverria,William R. Sellers,Charles Voliva +24 more
TL;DR: The biologic characterization of the 2-morpholino pyrimidine derivative pan-PI3K inhibitor NVP-BKM120 shows dose-dependent in vivo pharmacodynamic activity as measured by significant inhibition of p-Akt and tumor growth inhibition in mechanistic xenograft models and behaves synergistically when combined with either targeted agentssuch as MEK or HER2 inhibitors or with cytotoxic agents such as docetaxel or temozolomide.
Journal ArticleDOI
Characterization of the Novel and Specific PI3Kα Inhibitor NVP-BYL719 and Development of the Patient Stratification Strategy for Clinical Trials
Christine Fritsch,Alan Huang,Christian Chatenay-Rivauday,Christian Schnell,Anupama Reddy,Manway Liu,Audrey Kauffmann,Daniel Guthy,Dirk Erdmann,Alain De Pover,Pascal Furet,Hui Gao,Stephane Ferretti,Youzhen Wang,Joerg Trappe,Saskia M. Brachmann,Sauveur-Michel Maira,Christine D. Wilson,Markus Boehm,Carlos Garcia-Echeverria,Patrick Chène,Marion Wiesmann,Robert Cozens,Joseph Lehar,Robert Schlegel,Giorgio Caravatti,Francesco Hofmann,William R. Sellers +27 more
TL;DR: The biologic properties of the 2-aminothiazole derivative NVP-BYL719, a selective inhibitor of PI3Kα and its most common oncogenic mutant forms, are reported and it is found that PIK3CA mutation was the foremost positive predictor of sensitivity while revealing additional positive and negative associations such as Pik3CA amplification and PTEN mutation, respectively.
Journal ArticleDOI
Molecular characterization of the hdm2-p53 interaction.
Angelika Böttger,Volker Böttger,Carlos Garcia-Echeverria,Patrick Chène,Heinz-Kurt Hochkeppel,Wayne Sampson,Kiah Ang,Stephanie F. Howard,Steven M. Picksley,David P. Lane +9 more
TL;DR: The p53-hdm2 interaction biochemically is characterized and the potential of a series of peptide inhibitors, derived from previously described mdm2 binding peptide display phage, to disrupt this interaction in ELISA assays are analysed.