K
Klaas Nico Faber
Researcher at University Medical Center Groningen
Publications - 176
Citations - 6452
Klaas Nico Faber is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Medicine & Inflammatory bowel disease. The author has an hindex of 35, co-authored 134 publications receiving 4286 citations. Previous affiliations of Klaas Nico Faber include Erasmus University Rotterdam & University of Groningen.
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Journal ArticleDOI
Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases.
Daniela Parada Venegas,Marjorie De la Fuente,Glauben Landskron,María-Julieta González,Rodrigo Quera,Gerard Dijkstra,Hermie J. M. Harmsen,Klaas Nico Faber,Marcela A. Hermoso +8 more
TL;DR: An overview of microbial SCFAs production and their effects on the intestinal mucosa with specific emphasis on their relevance for Inflammatory Bowel Diseases is presented and the therapeutic potential ofSCFAs for IBD is discussed.
Journal ArticleDOI
Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump
Jacqueline R. M. Plass,O Mol,Janette Heegsma,M Geuken,Klaas Nico Faber,Peter L.M. Jansen,Michael Müller +6 more
TL;DR: Results show thatFXR is required for the bile salt–dependent transcriptional control of the human ABCB11 gene and that the cellular amount of FXR is critical for the level of activation ofABCB11 transcription.
Journal ArticleDOI
Drug transport proteins in the liver
TL;DR: Together with drug metabolising enzymes, transmembrane transporters are important determinants of drug metabolism and drug clearance by the liver and are subject to genetic polymorphism in the encoding genes as well as in these transcription factors.
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LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process
Marieke G. L. Elferink,Peter Olinga,Annelies L. Draaisma,Marjolijn T. Merema,Klaas Nico Faber,Maarten J. H. Slooff,Dirk K. F. Meijer,Geny M. M. Groothuis +7 more
TL;DR: It is shown that posttranscriptional mechanisms play a more prominent role in LPS-induced regulation of human MRP2 and BSEP compared with the rat transporter proteins.
Journal ArticleDOI
Effects of active and passive smoking on disease course of Crohn's disease and ulcerative colitis
Frans van der Heide,Arie Dijkstra,Rinse K. Weersma,Frans A. Albersnagel,Elise M. van der Logt,Klaas Nico Faber,Wim J. Sluiter,Jan H. Kleibeuker,Gerard Dijkstra +8 more
TL;DR: Active smoking is a risk factor for CD, but does not affect the outcome; passive smoking is detrimental for the outcome of CD patients, and the data suggest that passivesmoking is a novel risk factors for CD.