K
Kumiko Hongo
Researcher at University of Tokyo
Publications - 26
Citations - 833
Kumiko Hongo is an academic researcher from University of Tokyo. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 14, co-authored 24 publications receiving 752 citations.
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Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells
Kazuhito Sasaki,Nelson H. Tsuno,Eiji Sunami,Giichiro Tsurita,Kazushige Kawai,Yurai Okaji,Takeshi Nishikawa,Yasutaka Shuno,Kumiko Hongo,Masaya Hiyoshi,Manabu Kaneko,Joji Kitayama,Koki Takahashi,Hirokazu Nagawa +13 more
TL;DR: The findings suggest that the combination therapy with CQ should be a novel therapeutic modality to improve efficacy of 5-FU-based chemotherapy, possibly by inhibiting autophagy-dependent resistance to chemotherapy.
Journal ArticleDOI
Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells
Takeshi Nishikawa,Nelson H. Tsuno,Yurai Okaji,Yasutaka Shuno,Kazuhito Sasaki,Kumiko Hongo,Eiji Sunami,Joji Kitayama,Koki Takahashi,Hirokazu Nagawa +9 more
TL;DR: The present results demonstrate induction of autophagy in colon cancer cells as a protective reaction against the proapoptotic effect of SUL, and consequently, the potentiation of the proAP optotic effect by autophagosomes inhibition.
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Elevated Neutrophil to Lymphocyte Ratio Predicts Poor Prognosis in Advanced Colorectal Cancer Patients Receiving Oxaliplatin-Based Chemotherapy
Manabu Kaneko,Hiroaki Nozawa,Kazuhito Sasaki,Kumiko Hongo,Masaya Hiyoshi,Noriko Tada,Koji Murono,Takako Nirei,Kazushige Kawai,Eiji Sunami,Nelson H. Tsuno,Joji Kitayama +11 more
TL;DR: Elevated NLR is a powerful predictor of poor response to oxaliplatin-based chemotherapy in patients with unresectable CRC, and is a simply accessible and inexpensive but useful biomarker in CRC patients receiving chemotherapy.
Journal ArticleDOI
Resistance of colon cancer to 5-fluorouracil may be overcome by combination with chloroquine, an in vivo study.
Kazuhito Sasaki,Nelson H. Tsuno,Eiji Sunami,Kazushige Kawai,Kumiko Hongo,Masaya Hiyoshi,Manabu Kaneko,Koji Murono,Noriko Tada,Takako Nirei,Koki Takahashi,Joji Kitayama +11 more
TL;DR: The findings suggest that the combination therapy of CQ and 5-FU should be considered as an effective strategy for the treatment of colorectal cancer.
Journal ArticleDOI
The inhibition of autophagy potentiates anti-angiogenic effects of sulforaphane by inducing apoptosis
Takeshi Nishikawa,Nelson H. Tsuno,Yurai Okaji,Eiji Sunami,Yasutaka Shuno,Kazuhito Sasaki,Kumiko Hongo,Manabu Kaneko,Masaya Hiyoshi,Kazushige Kawai,Joji Kitayama,Koki Takahashi,Hirokazu Nagawa +12 more
TL;DR: Similar to cancer cells, ECs induced autophagy in response to the pro-apoptotic agent, SUL, and the inhibition of Autophagy potentiated the pro–angiogenic effect.