Leon R. Hirsch

TL;DR: In vivo studies under magnetic resonance guidance revealed that exposure to low doses of NIR light in solid tumors treated with metal nanoshells reached average maximum temperatures capable of inducing irreversible tissue damage, and found good correlation with histological findings.

TL;DR: A simple, non-invasive procedure that takes advantage of the strong near infrared (NIR) absorption of nanoshells, a new class of gold nanoparticles with tunable optical absorptivities that can undergo passive extravasation from the abnormal tumor vasculature due to their nanoscale size.

TL;DR: How the core/shell ratio and overall size of a nanoshell influences its scattering and absorption properties is illustrated and several examples ofnanoshell-based diagnostic and therapeutic approaches are described including the development of Nanoshell bioconjugates for molecular imaging, the use of scattering nanosells as contrast agents for optical coherence tomography (OCT), and the use for absorbing nanoshels in NIR thermal therapy of tumors.

TL;DR: A rapid immunoassay capable of detecting analyte within complex biological media without any sample preparation is described using gold nanoshells, layered dielectric-metal nanoparticles whose optical resonance is a function of the relative size of its constituent layers.

TL;DR: In this paper, the surface enhanced Raman scattering (SERS) response of nonresonant molecular adsorbates (para-mercaptoaniline) bound to the nanoparticle surface was measured.