L
Luc A. Sabourin
Researcher at University of Ottawa
Publications - 56
Citations - 6515
Luc A. Sabourin is an academic researcher from University of Ottawa. The author has contributed to research in topics: Focal adhesion & Myotonic dystrophy. The author has an hindex of 27, co-authored 54 publications receiving 6096 citations. Previous affiliations of Luc A. Sabourin include McMaster University & Children's Hospital of Eastern Ontario.
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Journal ArticleDOI
Pax7 is required for the specification of myogenic satellite cells.
Patrick Seale,Luc A. Sabourin,Adele Girgis-Gabardo,Ahmed Mansouri,Peter Gruss,Michael A. Rudnicki +5 more
TL;DR: The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts and it was demonstrated that satellite cells and muscle-derived stem cells represent distinct cell populations.
Journal ArticleDOI
Myotonic dystrophy mutation: an unstable CTG repeat in the 3' untranslated region of the gene
Mani S. Mahadevan,Catherine Tsilfidis,Luc A. Sabourin,G Shutler,Chris T. Amemiya,G Jansen,Catherine E. Neville,Monica Narang,Juana Barceló,K O'Hoy +9 more
TL;DR: Increases in the size of the allele in patients with DM are now shown to be due to an increased number of trinucleotide CTG repeats in the 3' untranslated region of a DM candidate gene.
Journal ArticleDOI
The molecular regulation of myogenesis.
TL;DR: A functional role for MyoD during satellite cell activation and muscle repair has been identified in vivo, which cannot be substituted for by the other MRFs, putting forward the hypothesis that these factors also play specific biological roles following muscle injury and repair.
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Reduced Differentiation Potential of Primary MyoD−/− Myogenic Cells Derived from Adult Skeletal Muscle
TL;DR: Northern analysis and Mixing of lacZ-labeled MyoD−/− cells and wild-type myoblasts revealed a strict autonomy in differentiation potential, and interpret these data to suggest that Myo D−/+ myogenic cells represent an intermediate stage between a quiescent satellite cell and a myogenic precursor cell.
Journal ArticleDOI
Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene
Mani S. Mahadevan,Chris T. Amemiya,G Jansen,Luc A. Sabourin,Stephen Baird,Catherine E. Neville,Nicole Wormskamp,B Segers,Mark A. Batzer,Jane Lamerdin +9 more
TL;DR: The complete sequence and characterization of the structure of the DM kinase gene, as well as the identification of novel polymorphisms within the gene, represent an important step in a further understanding of the genetics of myotonic dystrophy and the molecular biology of the gene.