M
Michael A. Rudnicki
Researcher at Innsbruck Medical University
Publications - 327
Citations - 49102
Michael A. Rudnicki is an academic researcher from Innsbruck Medical University. The author has contributed to research in topics: Stem cell & Myogenesis. The author has an hindex of 98, co-authored 311 publications receiving 44258 citations. Previous affiliations of Michael A. Rudnicki include Ontario Genomics Institute & McMaster University.
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Journal ArticleDOI
Cellular and Molecular Regulation of Muscle Regeneration
TL;DR: Recent evidence supports the possible contribution of adult stem cells in the muscle regeneration process and in particular, bone marrow-derived and muscle-derived stem cells contribute to new myofiber formation and to the satellite cell pool after injury.
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Pax7 is required for the specification of myogenic satellite cells.
Patrick Seale,Luc A. Sabourin,Adele Girgis-Gabardo,Ahmed Mansouri,Peter Gruss,Michael A. Rudnicki +5 more
TL;DR: The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts and it was demonstrated that satellite cells and muscle-derived stem cells represent distinct cell populations.
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PRDM16 controls a brown fat/skeletal muscle switch
Patrick Seale,Bryan C. Bjork,Wenli Yang,Shingo Kajimura,Sherry Chin,Shihuan Kuang,Anthony Scimè,Srikripa Devarakonda,Heather M. Conroe,Hediye Erdjument-Bromage,Paul Tempst,Michael A. Rudnicki,David R. Beier,Bruce M. Spiegelman +13 more
TL;DR: It is shown by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage.
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MyoD or Myf-5 is required for the formation of skeletal muscle
Michael A. Rudnicki,Patrick N. J. Schnegelsberg,R. H. Stead,Thomas Braun,Hans-Henning Arnold,Rudolf Jaenisch +5 more
TL;DR: Observations suggest that either Myf-5 or MyoD is required for the determination of skeletal myoblasts, their propagation, or both during embryonic development and indicate that these factors play, at least in part, functionally redundant roles in myogenesis.
Journal ArticleDOI
Satellite Cells and the Muscle Stem Cell Niche
TL;DR: For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved the understanding of skeletal muscle biology, with focuses on functions of satellite cells and their niche during the process ofletal muscle regeneration.