L
Lucy X. Morris
Researcher at Australian National University
Publications - 3
Citations - 2706
Lucy X. Morris is an academic researcher from Australian National University. The author has contributed to research in topics: Pyroptosis & Inflammasome. The author has an hindex of 3, co-authored 3 publications receiving 1614 citations.
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Journal ArticleDOI
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more
TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
Journal ArticleDOI
NINJ1 mediates plasma membrane rupture during lytic cell death
Nobuhiko Kayagaki,Opher S. Kornfeld,Bettina L. Lee,Irma B. Stowe,Karen O'Rourke,Qingling Li,Wendy Sandoval,Donghong Yan,Jing Kang,Min Xu,Juan Zhang,Wyne P. Lee,Brent S. McKenzie,Gözde Ulas,Jian Payandeh,Merone Roose-Girma,Zora Modrusan,Rohit Reja,Meredith Sagolla,Joshua D. Webster,Vicky Cho,T. Daniel Andrews,Lucy X. Morris,Lisa A. Miosge,Christopher C. Goodnow,Christopher C. Goodnow,Edward M. Bertram,Vishva M. Dixit +27 more
TL;DR: In this article, the authors showed that the cell-surface NINJ1 protein, which contains two transmembrane regions, has an essential role in the induction of PMR.
Journal ArticleDOI
IRF2 transcriptionally induces GSDMD expression for pyroptosis.
Nobuhiko Kayagaki,Bettina L. Lee,Irma B. Stowe,Opher S. Kornfeld,Karen O'Rourke,Kathleen M. Mirrashidi,Benjamin Haley,Colin K. Watanabe,Merone Roose-Girma,Zora Modrusan,Sarah K. Kummerfeld,Rohit Reja,Yafei Zhang,Vicky Cho,T. Daniel Andrews,Lucy X. Morris,Christopher C. Goodnow,Christopher C. Goodnow,Edward M. Bertram,Vishva M. Dixit +19 more
TL;DR: It is shown that IRF2, a member of the interferon regulatory factor (IRF) family of transcription factors, was essential for the transcriptional activation of GSDMD, a critical mediator of inflammatory pathologies.