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Guy S. Salvesen

Researcher at Discovery Institute

Publications -  342
Citations -  80506

Guy S. Salvesen is an academic researcher from Discovery Institute. The author has contributed to research in topics: Caspase & Apoptosis. The author has an hindex of 116, co-authored 337 publications receiving 75598 citations. Previous affiliations of Guy S. Salvesen include Johns Hopkins University School of Medicine & Purdue University.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter, +6 more
- 01 Mar 1993 - 
TL;DR: It is demonstrated that there was a highly significant association of apolipoprotein E type 4 allele (APOE-epsilon 4) and late-onset familial Alzheimer disease.
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Regulation of Cell Death Protease Caspase-9 by Phosphorylation

Michael H. Cardone, +7 more
- 13 Nov 1998 - 
TL;DR: In this paper, the kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro-caspase-9 (pro-Casp9) in cells.
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Human ICE/CED-3 Protease Nomenclature

Emad S. Alnemri, +6 more
- 18 Oct 1996 - 
TL;DR: A committee of several scientists who have been involved in the identification and characterization of these enzymes have formed a committee, with the objective of proposing a nomenclature for the human members of this protease family that is sensible and easy to use.
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Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

Muneesh Tewari, +8 more
- 02 Jun 1995 - 
TL;DR: It is proposed that Yama may represent an effector component of the mammalian cell death pathway and suggest that CrmA blocks apoptosis by inhibiting Yama.