Malcolm R. DeBaun

TL;DR: This review provides an overview of the current operative treatment strategies of critical-sized bone defects as well as the current state of tissue engineering for such defects.

TL;DR: Evidence of its efficacy has been highly variable depending on the specific indication, and additional high-quality clinical trials with longer follow-up will be critical in shaping the perspective of this treatment option.

TL;DR: Evidence of PRP efficacy has been mixed and highly variable depending on the specific indication, and sweeping recommendations about its utility impossible to make are likely to make.

TL;DR: Assessment of the enrichment of stem/progenitor cells and growth factors in BM aspirate by two different commercial concentration devices versus standard BM aspiration contributed to the development of BMAC quality control assays as both BMAC systems concentrated platelets, growth factors and non-hematopoietic stem cell subpopulations with distinct phenotypes without loss of cell viability.

TL;DR: In this article, relaxin binding to receptors on female ACL cells was shown to result in an increase in matrix metalloproteinase (MMP) and decrease in tissue inhibitor of TIMP gene expression, a decrease in collagen and alpha smooth muscle actin (αSMA) expression, inhibition of transforming growth factor β1 (TGFβ1)induced fibrosis, and an increase of cyclic adenosine 3′,5′-monophosphate (cAMP) production.